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acquired activation algorithm anemia extravascular gap globulin hemolysis hemolytic hodgkins intravascular macrophage mas oncology protein proteingap sapho sjogrens spleen splenomegaly
Causes of Splenomegaly - Differential Diagnosis Algorithm Infectious • Bacterial • Viral (EBV) • Parasitic • Fungal Congestive
- Differential ... Congestive • Cirrhosis ... Malignant • Lymphoma ... Splenomegaly #Spleen #Enlarged ... #Causes #Hematology
Acquired von Willebrand Syndrome - Diagnosis and Management • Autoantibodies to vWF: Lymphoproliferative disorders (e.g. lymphoma,
. lymphoma, multiple ... thrombocythemia), Autoimmune disease ... #Diagnosis #Management ... #treatment #hematology ... #differential
Diagnostic Framework for Hemolysis - Intravascular vs Extravascular Causes Intravascular Hemolysis: • Mechanical Trauma (Microangiopathic hemolytic anemia):
Diagnostic Framework ... Extravascular Causes ... . lupus, CLL, lymphoma ... #differential # ... diagnosis #hematology
Sjogren's Syndrome Overview Epidemiology: • F > M: 9:1 • 5-6th Decades (can be any age) Autoimmune exocrinopathy multisystemic disease
Hypocomplementemia • Can cause ... primary biliary cirrhosis ... Adenocarcinoma Treatment ... #Rheumatology # ... Diagnosis #Management
Hodgkin's Lymphoma Overview Hodgkin's lymphoma (HL) is an uncommon hematological malignancy arising from mature B cells. It
number of sites of disease ... Treatment • Early ... #diagnosis #classification ... #hematology #oncology ... #management
Macrophage Activation Syndrome (MAS) Classified among the secondary or acquired forms of haemophagocytic lymphohistiocytosis (sHLH) What? A subset of
nervous system (CNS ... • Infection (eg ... Treatment: • Corticosteroids ... #Diagnosis #Management ... #Hematology #Rheumatology
SAPHO Syndrome Summary What? SAPHO syndrome is a rare chronic inflammatory disorder of bone, joint, and skin characterized
Rule out other causes ... and lower jaw Treatment ... #Rheumatology # ... diagnosis #management ... #Dermatology
Elevated Globulin - Protein Gap (Total Protein - Albumin > 4) Work-up of an Elevated Globulin Gap: •
changes (POEMS syndrome ... : Cirrhosis, ETOH ... gastric tumors • Hematology ... Gap #ProteinGap #differential ... #diagnosis #hematology
TAFRO TAFRO syndrome was first described in 2010, standing for: - Thrombocytopenia - Anasarca - Fever - Reticulin fibrosis - Organomegaly TAFRO syndrome
mesothelioma, etc ... IGG4 - Hepatic cirrhosis ... Histopathological Diagnoses ... Hypoalbuminemia Treatment ... #management #rheumatology
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