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diagnosis algorithm hemolytic macrocytosis agglutinin approach cold cryoglobulinemia cryoglobulins dermatology extravascular gap globulin hemolysis macrocytic microcytic nonpalpable palpable platelet protein
Diagnostic Framework for Hemolysis - Intravascular vs Extravascular Causes Intravascular Hemolysis: • Mechanical Trauma (Microangiopathic hemolytic anemia):
Causes Intravascular ... lymphoproliferative disorders ... #Causes #differential ... #diagnosis #hematology ... #anemia
Causes of Anemia with elevated Mean Corpuscular Volume (MCV) - Differential Diagnosis Algorithm Normal Blood Smear •
Causes of Anemia ... Corpuscular Volume (MCV ... • Small Bowel Disorder ... Myelodysplastic Syndromes ... #Hematology
Causes of Anemia by Mean Corpuscular Volume (MCV) - Differential Diagnosis Algorithm Low Mean Corpuscular Volume (<80
Causes of Anemia ... ) - Differential ... (e.g. ... #MCV #Classification ... #Hematology
Causes of Anemia with Low Mean Corpuscular Volume (MCV) - Differential Diagnosis Algorithm Decreased Heme Synthesis or
Causes of Anemia ... ) - Differential ... HgbE, HgbC, etc. ... #Macrocytosis #elevatedMCV ... #Hematology
Overall Approach to Anemia - Differential Diagnosis Algorithm Blood Loss • Acute Bleed - Normocytic / Normochromic
Reticulocytes, MCV ... Disease • Marrow ... #Classification ... Diagnosis #Algorithm #Causes ... #Hematology
Causes of Thrombocytopenia and Platelet Disorders - Differential Diagnosis and Workup History: - Prior platelet count, family
- Differential ... anemia (vegan, ... ITP, unexplained pancytopenia ... #Differential # ... #Workup #hematology
Purpura - Differential Diagnosis Framework Non-blanchable, dark red to purple, hemorrhagic skin lesions that result from leakage
Purpura - Differential ... - Hemolytic anemia ... • HCV, HBV Not ... #Diagnosis #hematology ... #rheumatology #
Cold Agglutinin Disease 3 Types of Cold Sensitive Antibodies: 1. Cold Agglutinins (CAD) 2. Donath-Landsteiner
Cold Agglutinin Syndrome ... • Symptoms of anemia ... younger pts) Differential ... the RBCs causing intravascular ... #hematology #diagnosis
Cryoglobulinemia Summary Cryoglobulins: • Cryoglobulins are Igs in the serum that precipitate in vitro at temperatures below
• They can cause ... Cryoglobulins Cause ... • Autoimmune diseases ... diagnosis #types #classification ... #rheumatology #
Elevated Globulin - Protein Gap (Total Protein - Albumin > 4) Work-up of an Elevated Globulin Gap: •
Causes of Monoclonal ... changes (POEMS syndrome ... Connective tissue disorders ... gastric tumors • Hematology ... #diagnosis #hematology
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