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management coagulation abnormal blood intravascular prolonged activation anemia bruising disorders extravascular hemolysis hemolytic hemostasis macrophage mas platelet thrombocytopenia transfusion transfusions
Differential Diagnosis for a Prolonged PT and aPTT If the PT and the aPTT are both prolonged,
Differential Diagnosis ... PT and the aPTT ... • Reduced liver ... #Causes #diagnosis ... hematology #coagulation
Causes of Abnormal PT and/or aPTT Prolonged Prothrombin Time (PT) 1. Acquired deficiency of FVII
PT and/or aPTT ... Early liver disease ... #Causes #diagnosis ... #differential # ... hematology #coagulation
Disseminated Intravascular Coagulation (DIC) Overview Increased Clotting and Consumption of Clotting Factors Findings: • Bleeding • Recent history
• Severe Liver ... Disease: - Impaired ... #DIC #Disseminated ... #Coagulation #diagnosis ... #management #hematology
Diagnostic Framework for Hemolysis - Intravascular vs Extravascular Causes Intravascular Hemolysis: • Mechanical Trauma (Microangiopathic hemolytic anemia):
Diagnostic Framework ... anemia): - Disseminated ... intravascular coagulation (DIC ... #differential # ... diagnosis #hematology
Causes of Thrombocytopenia and Platelet Disorders - Differential Diagnosis and Workup History: - Prior platelet count, family
Diagnosis and Workup ... : INR/PT, aPTT(liver ... disease), HBsAg ... #Diagnosis #Causes ... #Workup #hematology
Bleeding and Bruising - Disorders of Hemostasis - Differential Diagnosis Framework == Quantitative or Qualitative defect in
von Willebrand syndrome ... PTT suggests liver ... failure, disseminated ... discern these causes ... #Diagnosis #Hematology
Blood Product Transfusions One Pager Summary Type and screen - determines blood type and detects in recipient
in recipient (e.g ... pain, dark urine, DIC ... eruptions, diarrhea, liver ... #Transfusions #diagnosis ... #management #hematology
Macrophage Activation Syndrome (MAS) Classified among the secondary or acquired forms of haemophagocytic lymphohistiocytosis (sHLH) What? A subset of
purpura to mucosal bleeding ... thrombocytopenia • Liver ... degradation products ... #Diagnosis #Management ... #Hematology #Rheumatology
Blood Transfusion Reactions Immune Mediated: • Febrile Non-Hemolytic Transfusion Reaction (FNHTR): Most common immune reaction to transfusion.
pain, dark urine, DIC ... haptoglobin, ↑LDH, etc ... eruptions, diarrhea, liver ... #Transfusion #diagnosis ... #management #hematology
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