ecg qtc syndrome acltear hematology disease differential classification causes rheumatology diagnosis vasculitis secondary pain algorithm agglutinin aortitis lupus anemia

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Aortitis - Differential Diagnosis Framework
Non-Infectious Aortitis:
• Vasculitides: Giant Cell Arteritis (GCA), Takayasu's arteritis, Cogan's Syndrome,

Aortitis - Differential ... : • Vasculitides ... arteritis, Cogan's Syndrome ... (RA), Systemic lupus ... Diagnosis #rheumatology

Diagnostic Framework for Hemolysis - Intravascular vs Extravascular Causes
Intravascular Hemolysis:
• Mechanical Trauma (Microangiopathic hemolytic anemia):

Diagnostic Framework ... . lupus, CLL, lymphoma ... . primary cold agglutin ... #differential # ... diagnosis #hematology

Cold Agglutinin Disease

3 Types of Cold Sensitive Antibodies:
1. Cold Agglutinins (CAD)
2. Donath-Landsteiner

Cryoglobulins (Vasculitic ... Syndrome (CAS): ... younger pts) Differential ... chills, flank pain ... #anemia #hematology

Vasculitis and Vasculitides - Differential Diagnosis Framework

When to Consider Vasculitis:
• Purpura, ischemic skin lesions
•

tract, and often causes ... claudication, aortitis ... differential #diagnosis ... #rheumatology # ... classification

SLE (Systemic Lupus Erythematosus)

Suspect:
Clinical evidence of (fatigue, rash, photosensitivity, inflammatory arthritis, weight loss, and fever) and

Classification: ... permanent alopecia Differential ... Arthritis: • Joint pain ... lymphopenia, low PLT • Anemia ... #Rheumatology

Cryoglobulinemia Summary

Cryoglobulins:
• Cryoglobulins are Igs in the serum that precipitate in vitro at temperatures below

• Autoimmune diseases ... Type III Often Secondary ... . systemic lupus ... #types #classification ... #rheumatology #

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