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management oncology algorithm anemia atlas bloodcell chronic cryoglobulinemia cryoglobulins dermatology erythematosus extravascular fatigue gap globulin hemolytic hodgkins intravascular joint lupus
Diagnostic Framework for Hemolysis - Intravascular vs Extravascular Causes Intravascular Hemolysis: • Mechanical Trauma (Microangiopathic hemolytic anemia):
Diagnostic Framework ... Extravascular Causes ... lymphoproliferative disorders ... #differential # ... diagnosis #hematology
Causes of Thrombocytosis - Differential Diagnosis Secondary Thrombocytosis (a.k.a Reactive Thrombocytosis): • Acute infection • Solid organ
iron deficiency, hemolysis ... (e.g. autoimmune ... Myelodysplastic syndrome ... #Diagnosis #Causes ... #hematology #secondary
Red Blood Cell (RBC) Morphology Microcytic RBC: Pyridoxine deficiency, Thalassemia, Iron deficiency anemia, Chronic disease anemia (sometimes),
Chemotherapy (e.g ... Unstable hemoglobin disorders ... spherocytosis, Autoimmune ... RBC #Morphology #differential ... #diagnosis #hematology
Causes of Fatigue - Differential Diagnosis Algorithm Endocrine • Hypo/Hyperthyroidism • Diabetes • Pituitary Insufficiency • Adrenal
Neoplastic / Hematologic ... Hepatitis • HIV Autoimmune ... • Rheumatoid Arthritis ... • Somatization Disorder ... Chronic Fatigue Syndrome
Cryoglobulinemia Summary Cryoglobulins: • Cryoglobulins are Igs in the serum that precipitate in vitro at temperatures below
• They can cause ... Cryoglobulins Cause ... diseases: - 10% ... #types #classification ... #rheumatology #
SLE (Systemic Lupus Erythematosus) Suspect: Clinical evidence of (fatigue, rash, photosensitivity, inflammatory arthritis, weight loss, and fever) and
Classification: ... permanent alopecia Differential ... rheumatologic diseases ... (e.g. thyroid disease ... #Rheumatology
Approach to Joint Pain - Arthritis Differential Diagnosis Framework Inflammatory Versus Noninflammatory Pain • Is it inflammatory
Differential Diagnosis ... Mechanical/degenerative disorders ... weeks) Can Be Caused ... Rheumatologic Disease ... #rheumatology #
SAPHO Syndrome Summary What? SAPHO syndrome is a rare chronic inflammatory disorder of bone, joint, and skin characterized
chronic inflammatory disorder ... nonerosive inflammatory arthritis ... Rule out other causes ... osteoarticular and skin disease ... #Rheumatology #
Hodgkin's Lymphoma Overview Hodgkin's lymphoma (HL) is an uncommon hematological malignancy arising from mature B cells. It
disorders Hodgkin ... nodosum • Immune hemolytic ... Hodgkin Lymphoma Workup ... number of sites of disease ... #hematology #oncology
Myelodysplastic Syndromes (MDS) What? Myelodysplastic syndromes are a group of disorders caused by blood cells that are poorly
formed or don’t work ... Easy or unusual bruising ... Myeloproliferative Disease ... blood count with differential ... #diagnosis #hematology
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