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diagnosis hodgkins management vasculitis algorithm anemia comparison cryoglobulins erythematosus extravascular focal hemolysis hemolytic intravascular leukemia lupus lymphadenopathy mds myelodysplasia myelodysplastic
Causes of Localized Lymphadenopathy - Differential Diagnosis Algorithm Cervical: - Anterior • Infection
Causes of Localized ... • Kikuchi Disease ... Tularemia • Secondary ... Lymphadenopathy #LAD ... #Hematology #Oncology
Hodgkin's Lymphoma vs Non-Hodgkin's Lymphoma - Comparison Hodgkin's Lymphoma: • Epidemiology: young adults 20-30, older 50-70 •
Adenopathy (painless)-localized ... diseases (e.g., ... translocation • Types: Classification ... NonHodgkins #comparison #oncology ... #hematology
Diagnostic Framework for Hemolysis - Intravascular vs Extravascular Causes Intravascular Hemolysis: • Mechanical Trauma (Microangiopathic hemolytic anemia):
Extravascular Causes ... . lupus, CLL, lymphoma ... , Copper and lead ... #differential # ... diagnosis #hematology
Cryoglobulinemia Summary Cryoglobulins: • Cryoglobulins are Igs in the serum that precipitate in vitro at temperatures below
• They can cause ... diseases: - 10% ... Type III Often Secondary ... diagnosis #types #classification ... #rheumatology #
Sjogren's Syndrome Overview Epidemiology: • F > M: 9:1 • 5-6th Decades (can be any age) Autoimmune exocrinopathy multisystemic disease
• Secondary form ... Hypocomplementemia • Can cause ... Nephrogenic DI Hematologic ... Vasculitis: • 7%, Cryoglobulinemia ... #Rheumatology #
Hodgkin's Lymphoma Overview Hodgkin's lymphoma (HL) is an uncommon hematological malignancy arising from mature B cells. It
Immunosuppression • Autoimmune ... Immunohistochemical studies (to differentiate ... number of sites of disease ... ABVD x 4 cycles + Localized ... #hematology #oncology
SLE (Systemic Lupus Erythematosus) Suspect: Clinical evidence of (fatigue, rash, photosensitivity, inflammatory arthritis, weight loss, and fever) and
Classification: ... permanent alopecia Differential ... rheumatologic diseases ... with Lupus: • Chronic ... Erythematosus #Diagnosis #Rheumatology
Leukemias Overview: ALL, CML, AML, APML, CLL Acute leukemias > 20% blasts in the peripheral blood smear
extramedullary disease ... activity • ↓ LAP ... bone marrow and secondary ... #Leukemia #Hematology ... #Oncology #Diagnosis
Vasculitis and Vasculitides - Differential Diagnosis Framework When to Consider Vasculitis: • Purpura, ischemic skin lesions •
Eosinophilia, asthma, chronic ... tract, and often causes ... retinopathy Lab ... #diagnosis #rheumatology ... #classification
Myelodysplastic Syndromes (MDS) What? Myelodysplastic syndromes are a group of disorders caused by blood cells that are poorly
DDX: Rule Out Secondary ... Marrow Failure • Chronic ... Myeloproliferative Disease ... #diagnosis #hematology ... #oncology
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