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vasculitis algorithm anemia cryoglobulinemia cryoglobulins dermatologic diffuse extravascular globulin gpa granulomatosis hemolysis hemolytic intravascular joint lad leukemia lymphadenopathy myopathy myositis
Causes of Diffuse Lymphadenopathy - Differential Diagnosis Algorithm Reactive: - Systemic Inflammatory •
• Systemic Lupus ... Erythematosus ... • Rheumatoid Arthritis ... #Causes #Hematology ... #Oncology
Skin Conditions Associated with Joint Pain Rash • Human parvovirus B19 infection Malar rash • SLE • Human parvovirus B19 infection •
Dermatomyositis Erythema chronicum ... lesions • Discoid lupus ... Sarcoidosis #dermatology ... #skin #rashes #differential ... #diagnosis #rheumatology
SLE (Systemic Lupus Erythematosus) Suspect: Clinical evidence of (fatigue, rash, photosensitivity, inflammatory arthritis, weight loss, and fever) and
Classification: ... permanent alopecia Differential ... rheumatologic diseases ... : • Chronic B-cell ... #Diagnosis #Rheumatology
Diagnostic Framework for Hemolysis - Intravascular vs Extravascular Causes Intravascular Hemolysis: • Mechanical Trauma (Microangiopathic hemolytic anemia):
Diagnostic Framework ... Extravascular Causes ... . lupus, CLL, lymphoma ... #differential # ... diagnosis #hematology
Dermatologic Manifestations of Granulomatosis with Polyangiitis (GPA) Skin involvement in granulomatosis with polyangiitis (GPA) is common and
GPA causes disease ... • Goodpasture syndrome ... • Giant cell arteritis ... #dermatology #rash ... #diagnosis #rheumatology
Cryoglobulinemia Summary Cryoglobulins: • Cryoglobulins are Igs in the serum that precipitate in vitro at temperatures below
diseases: - 10% ... Type III Often Secondary ... . systemic lupus ... erythematosus ( ... #rheumatology #
Vasculitis and Vasculitides - Differential Diagnosis Framework When to Consider Vasculitis: • Purpura, ischemic skin lesions •
Eosinophilia, asthma, chronic ... tract, and often causes ... erythematosus, ... #diagnosis #rheumatology ... #classification
Elevated Globulin - Protein Gap (Total Protein - Albumin > 4) Work-up of an Elevated Globulin Gap: •
changes (POEMS syndrome ... (RA, Temporal arteritis ... Cirrhosis, ETOH, autoimmune ... gastric tumors • Hematology ... #diagnosis #hematology
Leukemias Overview: ALL, CML, AML, APML, CLL Acute leukemias > 20% blasts in the peripheral blood smear
extramedullary disease ... activity • ↓ LAP ... bone marrow and secondary ... #Leukemia #Hematology ... #Oncology #Diagnosis
Autoimmune Myositis - Differential Diagnosis Framework Inflammatory Myopathies: Commonly symmetric proximal muscle weakness, no substantial muscle pain
- Differential ... • Nonerosive arthritis ... statins - probably caused ... Myositis #Myopathy #rheumatology ... #differential #
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