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Diagnostic Schema for Hyperferritinemia Pearl: Diseases associated with extreme elevations: 1. HLH 2. Still's disease 3. Systemic
HLH 2. ... histoplasmosis #Ferritin ... Differential #Diagnosis #Hematology
Hemophagocytic Lymphohistiocytosis (HLH) Clinical Features: Fever, Splenomegaly, Hepatomegaly, Lymphadenopathy, Confusion Classic lab findings in HLH: ↑↑ ferritin, Anemia,
Lymphohistiocytosis (HLH ... lab findings in HLH ... : ↑↑ ferritin, Anemia ... cell lines) • ↑ ferritin ... Lymphohistiocytosis #diagnosis #hematology
Causes of Hyperferritinemia - Differential Diagnosis Ferritin > 1000 Ferritin is the storage form of iron. Increased hepcidin
> 1000 Ferritin ... hepcidin prevents ferritin ... HLH or Adult Onset ... Hematologic Malignancy ... In adults, HLH is
Proposed Treatment Algorithm for MAS / HLH #MAS #HLH #Hemophagocytic #Lymphohistiocytosis #Management #Treatment #Algorithm #Hematology
Algorithm for MAS / HLH ... #MAS #HLH #Hemophagocytic ... Treatment #Algorithm #Hematology
Iron Panel Interpretation Iron deficiency - ↓ Iron, ↑-nl Transferrin / TIBC, ↓ Transferrin Saturation, ↓
Saturation, ↓ Ferritin ... Saturation, ↑-nl Ferritin ... Saturation, ↓-↑-nl Ferritin ... Saturation, ↑-nl Ferritin ... #differential #hematology
Hemophagocytic Lymphohistiocytosis (HLH) Definition: Overwhelming clinical syndrome associated with excessive macrophage activation and cytokine storm due to
Lymphohistiocytosis (HLH ... / Diagnosis: HLH ... cell activity • Ferritin ... If no response HLH ... management #treatment #hematology
COVID-19 Dermatologic Manifestations #covid19 #covidtoes #dermatology #dermatologic #COVID19 #sarscov2 #clinical #skin
COVID-19 Dermatologic ... covid19 #covidtoes #dermatology ... #dermatologic #
Pancytopenia - Workup and Differential Diagnosis Algorithm Consumption Disorders 1. Autoimmune Mediated Pancytopenia 2. Splenic Sequestration Peripheral Destruction
and Screen for HLH ... HLH syndrome 5. ... Diagnosis #Algorithm #Hematology
Hemophagocytic Lymphohistiocytosis (HLH) Pathophysiology: Triggering factor (infection,...)→Activation of CD8 T cells (IFN-y) → Excessive activation of macrophages
Lymphohistiocytosis (HLH ... dysfunction, ↑ Ferritin ... • Familial HLH ... XLP) Acquired HLH ... treatment #summary #rheumatology
Pancytopenia - Differential Diagnosis Congenital Diseases: • GATA2 deficiency • Fanconi’s anemia • Wiskott-Aldrich syndrome • Ribosomopathy or telomeropathy Cancer: • Leukemia • Lymphoma Inflammatory
erythematosus • HLH ... Differential #Diagnosis #Hematology
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