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Hemophagocytic Lymphohistiocytosis (HLH) Definition: Overwhelming clinical syndrome associated with excessive macrophage activation and cytokine storm due to
Presentation / Diagnosis ... Diagnosis via genetic ... cell activity • Ferritin ... Infection should be diagnosed ... #management #treatment
Hemophagocytic Lymphohistiocytosis (HLH) Pathophysiology: Triggering factor (infection,...)→Activation of CD8 T cells (IFN-y) → Excessive activation of macrophages
Auto-amplification loop Diagnosis ... dysfunction, ↑ Ferritin ... hemophagocytosis = additional diagnostic ... Lymphohistiocytosis #diagnosis ... #management #treatment
Macrophage Activation Syndrome (MAS) Classified among the secondary or acquired forms of haemophagocytic lymphohistiocytosis (sHLH) What? A subset of
lymphohistiocytosis (HLH ... hypersensitivity syndromes • HLH ... dehydrogenase • ↑ Ferritin ... Activation #Syndrome #Diagnosis ... #Management #Hematology
Diagnostic Schema for Hyperferritinemia Pearl: Diseases associated with extreme elevations: 1. HLH 2. Still's disease 3. Systemic
Diagnostic Schema ... HLH 2. ... histoplasmosis #Ferritin ... #Differential #Diagnosis
Hemophagocytic Lymphohistiocytosis (HLH) Clinical Features: Fever, Splenomegaly, Hepatomegaly, Lymphadenopathy, Confusion Classic lab findings in HLH: ↑↑ ferritin, Anemia,
: ↑↑ ferritin, Anemia ... IL-2 receptor Diagnostic ... Criteria): Molecular diagnosis ... cell lines) • ↑ ferritin ... Lymphohistiocytosis #diagnosis
Causes of Hyperferritinemia - Differential Diagnosis Ferritin > 1000 Ferritin is the storage form of iron. Increased hepcidin
- Differential Diagnosis ... Ferritin > 1000 ... HLH or Adult Onset ... In adults, HLH is ... #Differential #Diagnosis
Iron Panel Interpretation Iron deficiency - ↓ Iron, ↑-nl Transferrin / TIBC, ↓ Transferrin Saturation, ↓
Saturation, ↓ Ferritin ... Saturation, ↑-nl Ferritin ... Saturation, ↓-↑-nl Ferritin ... Saturation, ↑-nl Ferritin ... Interpretation #deficiency #diagnosis
Proposed Treatment Algorithm for MAS / HLH #MAS #HLH #Hemophagocytic #Lymphohistiocytosis #Management #Treatment #Algorithm #Hematology
Algorithm for MAS / HLH ... #MAS #HLH #Hemophagocytic ... Lymphohistiocytosis #Management
Hypoplastic Left Heart Syndrome (HLHS) • Introduction • Embryology • Anatomy • Physiology of HLHS •
Heart Syndrome (HLHS ... Physiology of HLHS ... Physical Exam/Diagnostic ... Pre-operative Management ... Options • Post-op Management
Iron Deficiency in Heart Failure - Diagnosis and Treatment Algorithm Diagnosis: Ferritin <100 ng/mL (absolute ID) OR
Heart Failure - Diagnosis ... Treatment Algorithm Diagnosis ... : Ferritin <100 ... absolute ID) OR Ferritin ... #management #algorithm
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