13 results
Macrophage Activation Syndrome (MAS)
Classified among the secondary or acquired forms of haemophagocytic lymphohistiocytosis (sHLH)

What?
A subset of
erythematosus [SLE ... ], AOSD) • Infection ... leukopenia, anemia, and thrombocytopenia ... Treatment: • Corticosteroids ... #Diagnosis #Management
Heparin Induced Thrombocytopenia (HIT) - Diagnosis and Management - GrepMed Handbook

Presentation: 
 • Plts ↓50% (nadir
Diagnosis and Management ... skin necrosis (at injection ... Confirmatory test ↑Se ... Management: • ... #Treatment #Hematology
Myasthenia Gravis Overview

Myasthenia Gravis is an autoimmune disorder of the postsynaptic neuromuscular junction.  Ab to
thyroid, Sjogren syndrome ... rheumatoid arthritis, SLE ... Miller Fischer and PCB ... precipitated by: Drugs, infection ... Gravis #diagnosis #management
Chronic Lymphocytic Leukemia - Summary

Cancer affecting lymphocytes/Mature B cell neoplasm
 • Lymphocytes accumulate in large numbers
non-Hodgkin lymphoma SLL ... weeks without infection ... Neutropenia, anemia, thrombocytopenia ... microglobulin Treatment ... • Richter’s Syndrome
Aplastic Anemia - Overview

Who?
• M = F
• 3 peaks:	1) Childhood	2) 15-25 years	3) >60 years

What?
• Aplastic anemia
Neutropenia - recurrent infections ... /fevers • Thrombocytopenia ... Idiopathic • Infections ... aplastic anemia Treatment ... #diagnosis #management
SLE (Systemic Lupus Erythematosus)

Suspect:
Clinical evidence of (fatigue, rash, photosensitivity, inflammatory arthritis, weight loss, and fever) and
erythematosus (SCLE ... Non-autoimmune rheumatologic ... fibromyalgia) • Infections ... La, anti-Jo-1, SCL ... Erythematosus #Diagnosis #Rheumatology
Differentiation Syndrome in APML
Epidemiology:
 • Incidence: common in APL (2-48% depending on the study)
 • Triggers:
Differentiation Syndrome ... Triggers: ATRA treatment ... Differential Diagnosis: Infection ... fluid overload, PCC ... APML #diagnosis #management
Myelodysplastic Syndromes (MDS)

What?
Myelodysplastic syndromes are a group of disorders caused by blood cells that are poorly
platelet count (thrombocytopenia ... petechiae) • Frequent infections ... IDUS) • Immune Thrombocytopenia ... • Parvovirus infection ... cells have DNA changes
TAFRO

TAFRO syndrome was first described in 2010, standing for:
- Thrombocytopenia
- Anasarca
- Fever
- Reticulin fibrosis
- Organomegaly

TAFRO syndrome
erythematosus (SLE ... histopathologic changes ... Hypoalbuminemia Treatment ... TAFRO #diagnosis #management ... #rheumatology #
SAPHO Syndrome Summary

What?
SAPHO syndrome is a rare chronic inflammatory disorder of bone, joint, and skin characterized
Sclerotic bone changes ... causes such as infectious ... and lower jaw Treatment ... #Rheumatology # ... diagnosis #management