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disease treatment hemophagocytic hlh lymphohistiocytosis oncology stills activation adultonset algorithm antibiotics aosd calcium chronic classification cll comparison deposition erythematosus febrile
“Step by Step” – the new kid on the block – aims to risk stratify this
” an infant with ... Procalcitonin <0.5 ng/mL ... CRP < 20 mg/L #Diagnosis ... #Management #Pediatrics ... #Peds #Febrile
Adult-Onset Still's Disease Clinical triad: Fever, Arthralgia/arthritis, Skin rash ± odynophagia + Biological inflammation: Increased neutrophils, Hyperferritinemia, decreased
Adult-Onset Still's ... Clinical triad: Fever ... Prunelle Getten ... #management #treatment ... #rheumatology
CPPD vs Gout == CPPD == Think About CPPD When: • Self-limited synovitis after surgery/trauma (> 65
locations: Wrist, MCP ... inflammatory response Risk ... 12-24 Hours • Fever ... Gout #Comparison #rheumatology ... #Diagnosis
Hemophagocytic Lymphohistiocytosis (HLH) Definition: Overwhelming clinical syndrome associated with excessive macrophage activation and cytokine storm due to
frequently affects infants ... also observed in adults ... following: • Fever ... #management #treatment ... #hematology
Adult Onset Still's Disease Systemic inflammation with urticarial rash. Rash: • Nonpruritic, evanescent (correlates with time of
Adult Onset Still's ... Ferritin >3000 ng/mL ... anti-lL6R, anti-ILI #Adult ... #rheumatology # ... management
Macrophage Activation Syndrome (MAS) Classified among the secondary or acquired forms of haemophagocytic lymphohistiocytosis (sHLH) What? A subset of
arthritis (sJIA) • Adult-onset ... 5000 to 10,000 ng/mL ... Activation #Syndrome #Diagnosis ... #Management #Hematology ... #Rheumatology
Hemophagocytic Lymphohistiocytosis (HLH) Pathophysiology: Triggering factor (infection,...)→Activation of CD8 T cells (IFN-y) → Excessive activation of macrophages
• Clinical: fever ... sIL-2R >2400 Ul/ml ... diseases: SLE+++, Adult-onset ... #management #treatment ... #summary #rheumatology
Chronic Lymphocytic Leukemia (CLL) - Summary Overview: • Most common leukemia in adults • Disorder of
common leukemia in adults ... ) B symptoms → fevers ... chemotherapy for low-risk ... Leukemia #oncology #hematology ... #management
Pseudogout Summary - Calcium Pyrophosphate Deposition Disease (CPPD) Pathophysiology: Pyrophosphate produced by chondrocytes likely precipitates with calcium to
locations: Wrist, MCP ... culture used to diagnose ... acute neck pain, fever ... Deposition #Disease #Rheumatology ... #diagnosis #management
SLE (Systemic Lupus Erythematosus) Suspect: Clinical evidence of (fatigue, rash, photosensitivity, inflammatory arthritis, weight loss, and fever) and
weight loss, and fever ... Differential Diagnosis ... rheumatoid arthritis, adult-onset ... Thrombosis highest risk ... #Rheumatology
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