17 results
Validation of the Step-By-Step Approach to Febrile Infants

#Diagnosis #Management #Pediatrics #Peds #Febrile #Infant #StepByStep #Algorithm #LP
#Diagnosis #Management ... #Pediatrics #Peds ... StepByStep #Algorithm #LP ... #Antibiotics #Risk ... Stratification #Fever
“Step by Step” – the new kid on the block – aims to risk stratify this
investigations and treatments ... CRP < 20 mg/L #Diagnosis ... #Management #Pediatrics ... #Peds #Febrile ... #Algorithm #LP
The Febrile Infant Step-by-Step Algorithm
This is an algorithm developed by European emergency physicians to identify low-risk
empiric antibiotic treatment ... #EBM #Management ... #Pediatrics #Peds ... StepByStep #Algorithm #LP ... Stratification #Fever
Adult-Onset Still's Disease
Clinical triad: Fever, Arthralgia/arthritis, Skin rash ± odynophagia
+ Biological inflammation: Increased neutrophils, Hyperferritinemia, decreased
Clinical triad: Fever ... Coxsackie, CMV, EBV ... Prunelle Getten ... #diagnosis #management ... #treatment #rheumatology
Hemophilia - Diagnosis and Management
Diagnosis:
 • Consistent bleeding history (unless screening for disease in family members
and Management ... Avoid meds that ... ↑ bleeding risk ... #Management #treatment ... #hematology
Hemophagocytic Lymphohistiocytosis (HLH)
Pathophysiology: Triggering factor (infection,...)→Activation of CD8 T cells (IFN-y) → Excessive activation of macrophages
• Clinical: fever ... • Autoimmune diseases ... Adult-onset Still disease ... Unknown cause Treatment ... #management #treatment
Hemophagocytic Lymphohistiocytosis (HLH)
Definition: Overwhelming clinical syndrome associated with excessive macrophage activation and cytokine storm due to
frequently affects infants ... age, however the disease ... following: • Fever ... #management #treatment ... #hematology
Adult Onset Still's Disease
Systemic inflammation with urticarial rash.
Rash: 
 • Nonpruritic, evanescent (correlates with time of
Ferritin >3000 ng/mL ... Treatment - Mild ... : NSAIDS Treatment ... #rheumatology # ... management
Macrophage Activation Syndrome (MAS)
Classified among the secondary or acquired forms of haemophagocytic lymphohistiocytosis (sHLH)

What?
A subset of
• Periodic fever ... 5000 to 10,000 ng/mL ... Treatment: • Corticosteroids ... Activation #Syndrome #Diagnosis ... #Management #Hematology
Chronic Lymphocytic Leukemia (CLL) - Summary
Overview: 
 • Most common leukemia in adults
 • Disorder of
) B symptoms → fevers ... chemotherapy for low-risk ... disease • Indications ... Leukemia #oncology #hematology ... #management