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Connective tissue disease-associated interstitial lung diseases

LIP: lymphoid interstitial pneumonia. NSIP: nonspecific interstitial pneumonia. OP: organizing pneumonia.
Connective tissue disease-associated ... diseases LIP ... connective tissue disease ... #Comparison #Table ... #Pulmonary #Rheumatology
COPD assessment and classification as proposed by GOLD 2001, 2006, 2011 and 2017 Reports. For further
Chronic Obstructive Lung ... Disease; mMRC: ... modified Medical ... #Diagnosis #Pulmonary ... #Comparison #Staging
Antinuclear Antibodies (ANA)
ANA or Anti-NucIear Antibody refers to antibodies against antigens in the nucleus → like
ANA ≠ Autoimmune Disease ... context of other symptoms ... , Interstitial Pulmonary ... ANA #patterns #rheumatology ... #diagnosis #differential
Systemic Lupus Erythematosus - Diagnosis
Manifestations:
 - Arthritis 69%
 - Malar rash 40%
 - Fever 36%
 -
Myositis 4% - Lung ... 60-70% - Anti-histone ... auto-immune, Infectious diseases ... sclerosis, Still's disease ... rheumatology
Pulmonary Renal Syndromes - OnePager Summary
Autoimmune ANCA vasculitis (AAV): GPA (granulomatous with polyangiitis), EGPA (eosinophilic granulomatosis
life-threatening diseases ... Inflammatory eye disease ... EGPA) • Auto-antibodies ... or serologies + symptoms ... sparing of the lung
Vasculitis and Vasculitides - Differential Diagnosis Framework

When to Consider Vasculitis:
 • Purpura, ischemic skin lesions
 •
disease, and ocular ... pain • Kawasaki Disease ... (Granulomatous disease ... atherosclerotic disease ... most important diseases
Vasculitis - Differential Diagnosis Framework

When to Consider Vasculitis:
• Purpura, ischemic skin lesions
• Mononeuritis multiplex
• Hematuria, proteinuria,
Systemic rheumatic diseases ... atherosclerotic disease ... most important diseases ... (GRANULOMATOUS DISEASE ... HBV Kawasaki Disease
Autoimmune Myositis - Differential Diagnosis Framework

Inflammatory Myopathies: Commonly symmetric proximal muscle weakness, no substantial muscle pain
disease Malignancy ... disease • Dysphagia ... disease • Myositis ... skeletal muscle disease ... myocarditis Other Diseases
Mycoses

HISTOPLASMOSIS
• Inhalation of conidia → Yeast → travel to lymph nodes → spread in body
• Bird
symptomsRheumatologic ... extrapulmonary disease ... or meningitic disease ... 40% Invasive Disease ... endocarditis Local Disease