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differential management hodgkins leukemia lymphoma acute anemia aplastic chronic classification cll comparison complications gammopathy mgus monoclonal myelitis neurology nonhodgkins pathophysiology
Chronic Lymphocytic Leukemia - Summary Cancer affecting lymphocytes/Mature B cell neoplasm • Lymphocytes accumulate in large numbers
Affects mainly older ... with no early symptoms ... Physical Exam/Signs ... #workup #oncology ... #hematology
Acute Rheumatic Fever: Pathogenesis and Clinical Findings Delayed autoimmune reaction -> Molecular mimicry -> GAS antigen cross-reacts with host ->
B and CD-4+ T cells ... -> Tissue injury ... Sydenham's Chorea Lymphocytes ... pathophysiology #diagnosis ... #signs #symptoms
Leukemias Overview: ALL, CML, AML, APML, CLL Acute leukemias > 20% blasts in the peripheral blood smear
rapid onset of symptoms ... chronic onset of symptoms ... Headaches, bone pain, fever ... #Leukemia #Hematology ... #Oncology #Diagnosis
Hodgkin's Lymphoma vs Non-Hodgkin's Lymphoma - Comparison Hodgkin's Lymphoma: • Epidemiology: young adults 20-30, older 50-70 •
adults 20-30, older ... Differential Diagnosis ... NonHodgkins #comparison #oncology ... #diagnosis #differential ... #hematology
Monoclonal Gammopathy of Undetermined Significance (MGUS) - Summary Framework Hematologic disorder characterized by the presence of either
Summary Framework Hematologic ... patients 50 years or older ... constitutional symptoms ... #Significance #hematology ... #diagnosis #oncology
Aplastic Anemia - Overview Who? • M = F • 3 peaks: 1) Childhood 2) 15-25 years 3) >60 years What? • Aplastic anemia
Marrow (Toxic injury ... index < 2 • EPO Level ... • Improve the symptoms ... Aplastic #Anemia #oncology ... #hematology #diagnosis
Hodgkin's Lymphoma Overview Hodgkin's lymphoma (HL) is an uncommon hematological malignancy arising from mature B cells. It
• Dyspnea • Fever ... ingestion • B symptoms ... lymph node biopsy (diagnostic ... classification #hematology ... #oncology #management
Transverse Myelitis Overview Focal inflammatory disorder of the spinal cord resulting in rapid onset of weakness, sensory
Presentation: Injury ... • Bilateral signs ... and/or symptoms ... defined sensory level ... Pleocytosis: Mild lymphocytic
Vasculitis - Differential Diagnosis Framework When to Consider Vasculitis: • Purpura, ischemic skin lesions • Mononeuritis multiplex • Hematuria, proteinuria,
Presentation: Systemic Symptoms ... purpura: Strong sign ... • Progressive symptoms ... elevated protein, lymphocytic ... #Rheumatology
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