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Hemophagocytic Lymphohistiocytosis (HLH) Pathophysiology: Triggering factor (infection,...)→Activation of CD8 T cells (IFN-y) → Excessive activation of macrophages
Lymphohistiocytosis (HLH) Pathophysiology ... Triggering factor (infection ... Acquired HLH: • Infections ... Still disease, Infection ... Etiological+++: Anti-infectious
Mycoses HISTOPLASMOSIS • Inhalation of conidia → Yeast → travel to lymph nodes → spread in body • Bird
Disseminated Infections ... 50% in chronic infection ... Aspergillosis Pathophysiology ... Fungal #Diagnosis #Management ... #Infections
Tuberculosis Overview 10 million new M. tuberculosis infections/year Facultative intracellular rod-shaped bacteria Multidrug-resistant tuberculosis (MDR-TB) accounts for 4.6% of
. tuberculosis infections ... for 4.6% of new infections ... HIV • Recent infection ... mycobacterial infection ... NTM) • Fungal infection
Tuberculosis Overview 10 million new M. tuberculosis infections/year Facultative intracellular rod-shaped bacteria Multidrug-resistant tuberculosis (MDR-TB) accounts for 4.6% of
. tuberculosis infections ... for 4.6% of new infections ... HIV • Recent infection ... mycobacterial infection ... NTM) • Fungal infection
SEPSIS AND SEPTIC SHOCK DEFINITION AND PATHOPHYSIOLOGY • Sepsis: Life-threatening organ dysfunction due to a dysregulated host
host response to infection ... inflammatory response to infection ... Without Shock): Infection ... ill patient with infection ... tests to identify infection
C.diff - Clostridioides Difficile Infection (CDI) - Diagnosis and Management - GrepMed Handbook Clinical Presentation + Progression:
Clostridioides Difficile Infection ... GrepMed Handbook Clinical ... Perforation) Pathophysiology ... #1 nosocomial infection ... #Clostridium #Infection
Guillain-Barré Syndrome (GBS) Acute autoimmune demyelinating polyradiculoneuropathy that presents with rapidly progressive flaccid weakness Epidemiology: • Incidence: 1
to a preceding infection ... • Most common infection ... jejuni • Other infections ... the underlying pathophysiology ... Syndrome #diagnosis #management
Transverse Myelitis Overview Focal inflammatory disorder of the spinal cord resulting in rapid onset of weakness, sensory
etiology unknown • Infectious ... Direct microbial infection ... cells: consider infectious ... be ordered • Infectious ... disorders • Infections
Emphysematous Cystitis Epidemiology: • Usually middle-aged diabetic women • Other RF: neurogenic bladder, urinary tract outlet obstruction,
immune compromise Clinical ... present or signs of infection ... Pathophysiology: ... also important Management ... Cystitis #diagnosis #management
IDSA Aspergillosis Treatment • Invasive pulmonary aspergillosis (IPA) • CNS aspergillosis • Cardiac Aspergillus infection •
Cardiac Aspergillus infection ... • Aspergillus infections ... of eye Infectious ... Aspergillosis #Treatment #management
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