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diagnosis rash apml dermatology differential differentiation erythematous hemophagocytic hlh infectiousdiseases leukostasis lymphohistiocytosis lysis nikolsky oncology schema treatment tumor
Erythematous Rashes - THE ALGORITHMIC APPROACH Characterized by diffuse redness of the skin due to capillary congestion, erythematous
or absence of fever ... If fever is present ... disease, scarlet fever ... but without a fever ... #Nikolsky #Febrile
ID Approach to Fever and Rash - Diagnostic Algorithm Central Maculopapular (most common): Measles, Parvovirus 819 / EBV,
ID Approach to Fever ... Desquamative: Scarlet fever ... Viral hemorrhagic fevers ... Questions @WuidQ #Fever ... #Rash #Febrile
Leukostasis vs Tumor Lysis Syndrome Leukostasis: • Pathophysiology: Large, immature blasts and high WBC count cause hyperviscosity
- 80% have fever ... Treatment: - If febrile ... leukapheresis - TLS ... #TLS #diagnosis ... #management #hematology
Differentiation Syndrome in APML Epidemiology: • Incidence: common in APL (2-48% depending on the study) • Triggers:
Differentiation Syndrome ... Subacute-Acute: • Common: fever ... Rare: DAH, acute febrile ... APML #diagnosis #management ... #hematology #oncology
Hemophagocytic Lymphohistiocytosis (HLH) Definition: Overwhelming clinical syndrome associated with excessive macrophage activation and cytokine storm due to
Overwhelming clinical syndrome ... acute or subacute febrile ... following: • Fever ... Lymphohistiocytosis #diagnosis #management ... #treatment #hematology
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