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differential myopathy neurology antibodies associations autoantibodies autoimmune clinical comparison dermatology idiopathic iims management msas myelitis rash specific transverse vasculitis weakness
Inflammatory Myopathies Dermatomyositis • Onset: Subacute • Pattern: Proximal • CK: Up to 50X ULN • Autoantibodies:
Inflammatory Myopathies ... Anti-MDA5, anti-Mi ... Inclusion Body Myositis ... #rheumatology # ... table
Idiopathic Inflammatory Myopathies (IIM's) RASH + MUSCLE WEAKNESS → Consider idiopathic inflammatory myopathies (IIM's) • Overlap Myositis
Myopathies (IIM's ... myopathies (IIM's ... • Overlap Myositis ... Inclusion body myositis ... #diagnosis #rheumatology
Myositis Specific Antibodies (MSAs) Dermatomyositis: MDA5, TIF1y, NXP2, Mi-2, SAE Anti-Synthetase Syndrome: Jo-1, PL7, PL12, EJ, OJ Immune Mediated
Myositis Specific ... , TIF1y, NXP2, Mi ... MSAs #clinical #diagnosis ... #rheumatology # ... table
Weakness - Differential Diagnosis Framework Approach To Weakness: • Non-neuromuscular disorder (Cardiac, pulmonary etc) • CNS ->
- Differential Diagnosis ... • Metabolic myopathies ... EMG) studies • MRI ... certain drug-induced myopathies ... #Differential #Diagnosis
Autoantibodies in Rheumatology • Lupus (SLE): ANA (anti-nuclear antibody), dsDNA (double-stranded DNA), Anti-Smith, Anti-Ro (SSA) and
Autoantibodies in Rheumatology ... Peptide (CCP) • Myositis ... , Others: SRP, Mi ... #diagnosis #associations ... #table
Transverse Myelitis Overview Focal inflammatory disorder of the spinal cord resulting in rapid onset of weakness, sensory
Overview Focal inflammatory ... bouts of HTN Diagnostic ... Diagnosis: • ... out compressive myelopathies ... Post Vaccine • Inflammatory
Vasculitis - Differential Diagnosis Framework When to Consider Vasculitis: • Purpura, ischemic skin lesions • Mononeuritis multiplex • Hematuria, proteinuria,
- Differential Diagnosis ... Conjunctivitis, mucositis ... oligoclonal bands • MRI ... syndrome: Ocular inflammatory ... #Rheumatology
Autoimmune Myositis - Differential Diagnosis Framework Inflammatory Myopathies: Commonly symmetric proximal muscle weakness, no substantial muscle pain
Framework Inflammatory ... Myopathies: Commonly ... , drug-induced myopathies ... RP-ILD), dermato-rheumatologic ... #Myopathy #rheumatology
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