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diagnosis management betadglucan galactomannan infectiousdiseases pulmonary abscess biomarkers causes chest comparison empyema en falsepositives granuloma humoral ia immunity immunology infections
Fungal Biomarkers: Beta-D-Glucan and Aspergillus Galactomannan Beta-D-Glucan: • Polysaccharide cell wall component of many fungi • Pathogens:
Fungal Biomarkers ... component of many fungi ... cut-offs defined in clinical ... GM does not differentiate ... Sara Dong #Fungal
Purple Urine Bag Syndrome Chronic, indwelling catheter + bacteriuria (Providencia, Klebsiella, E.coli*) + alkaline urine Tryptophan → Indoxyl
Purple Urine Bag ... Purple #Urine #Bag ... Syndrome #PUBS #pathophysiology ... #clinical #photo ... #differential #
Invasive Aspergillus (IA) - Diagnosis and Management Aspergillus is ubiquitous in nature. Most invasive infections are caused
HIV/AIDS, CGD) Clinical ... in SOT pts) • BAL ... this morphology Treatment ... Diagnosis #Management #treatment ... #fungal #infectiousdiseases
1,3-Beta-D-Glucan and Galactomannan Testing Sensitivity Specificity and False Positives 1,3-Beta-D-Glucan • Cell wall component of many fungi
component of many fungi ... cut-offs defined in clinical ... >90% (In most clinical ... does not differentiate ... closely related fungi
Empyema Necessitans (EN) on Chest Wall Physical Examination Pulmonary teaching case: you are called to the bedside
most common) - Fungus ... , Blastomyces, Aspergillus ... Fusobacterium Treatment ... covering the right bug ... #PhysicalExam #clinical
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 Humoral Immunity - Pathogenesis and Clinical Findings Antigens (Ag) are produced from pathogens (bacteria, viruses, fungi, parasites)
Pathogenesis and Clinical ... bacteria, viruses, fungi ... : Ag-presenting ... proliferate and differentiate ... Humoral #Immunity #pathophysiology
Lung Abscess - Diagnosis and Management Summary Lung Abscess Etiology: • Necrosis of lung parenchyma by a
Lung Abscess Pathophysiology ... Lung Abscess - Clinical ... Prevotella • Fungal ... Lung Abscess Differential ... Abscess #pulmonary #differential
Majocchi’s Granuloma due to Trichophyton rubrum This is GMS stain and culture of a skin biopsy
Treatment: Itraconazole ... Non-dermatophytes: Aspergillus ... Majocchi granuloma Treatment ... recommended Mayo Clinic ... #photo #microscopy
Mycoses HISTOPLASMOSIS • Inhalation of conidia → Yeast → travel to lymph nodes → spread in body • Bird
body • Bird and bat ... has five major clinical ... stain of clinical ... ASPERGILLOSIS • Aspergillus ... Aspergillosis Pathophysiology
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