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hematology chemotherapy chronic cll cyp3a4 differentiation doac inducers inhibitors interactions leukemia lymphocytic management mds myelodysplasia myelodysplastic pglycoprotein syndrome syndromes workup
Differentiation Syndrome in APML Epidemiology: • Incidence: common in APL (2-48% depending on the study) • Triggers:
Differentiation Syndrome in APML ... Triggers: ATRA treatment ... Renal Failure Treatment ... • Supportive Care ... #hematology #oncology
(DOAC interactions) Cancer-treatment specific inducers (↑) and inhibitors (↓) of cytochrome p450 CYP3A4 and P-glycoprotein. DOACs are substrates
interactions) Cancer-treatment ... DOACs are substrates ... #Chemotherapy #Oncology ... #Hematology #Interactions ... #Table #Pharmacology
Chronic Lymphocytic Leukemia - Summary Cancer affecting lymphocytes/Mature B cell neoplasm • Lymphocytes accumulate in large numbers
large numbers and are ... phenomenon CLL Diagnosis ... microglobulin Treatment ... #workup #oncology ... #hematology
Myelodysplastic Syndromes (MDS) What? Myelodysplastic syndromes are a group of disorders caused by blood cells that are poorly
factor (GCSF) treatments ... marrow studies Treatment ... Immunosuppressive treatment ... Myelodysplastic #Syndromes #diagnosis ... #hematology #oncology
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