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management hematology differential oncology syndrome behcet causes coagulation dic disseminated erythematosus fungal infections infectiousdiseases intravascular lupus monoclonal mycoses paraproteinemias signs
Leukemias Overview: ALL, CML, AML, APML, CLL Acute leukemias > 20% blasts in the peripheral blood smear
extramedullary disease ... involvement • 30%: CNS ... , weight loss, abdominal ... #Hematology #Oncology ... #Diagnosis
Behçet's Syndrome Systemic disease associated with inflammation of multiple organs, small-vessel vasculitis and large-vessel vasculopathy Epidemiology: • Young
ulceration • Ocular ... skin injury) • Neurologic ... tears, Ischemia, Leukemia ... • Nonsurgical abdominal ... signs #symptoms #rheumatology
Vasculitis - Differential Diagnosis Framework When to Consider Vasculitis: • Purpura, ischemic skin lesions • Mononeuritis multiplex • Hematuria, proteinuria,
- Differential Diagnosis ... affects the skin, neurologic ... multiplex • GI tract: Abdominal ... gut involvement, abdominal ... #Rheumatology
Sjogren's Syndrome Overview Epidemiology: • F > M: 9:1 • 5-6th Decades (can be any age) Autoimmune exocrinopathy multisystemic disease
Sjogren's Syndrome Diagnosis ... gland) biopsy • Ocular ... RTA, TYPE I RTA Diagnosis ... Sjogrens #Syndrome #Rheumatology ... #Diagnosis #Management
Disseminated Intravascular Coagulation (DIC) Overview Increased Clotting and Consumption of Clotting Factors Findings: • Bleeding • Recent history
promyelocytic leukemia ... Thromboembolism (7%) • CNS ... Schistocytes, helmet cells ... • Severe Liver Disease ... #Coagulation #diagnosis
SLE (Systemic Lupus Erythematosus) Suspect: Clinical evidence of (fatigue, rash, photosensitivity, inflammatory arthritis, weight loss, and fever) and
Erythematous, macular ... Differential Diagnosis ... Non-autoimmune rheumatologic ... Hodgkin lymphoma and leukemia ... #Rheumatology
Paraproteinemias Entities That Can Feature A Monoclonal Protein/M Component: • MM • WM • MGUS • MGCS • MGRS • Splenic Marginal Zone
• Heavy Chain disease ... et diutinum Neurologic ... Scleromyxedema (CNS ... Sneddon-Wilkinson disease ... #Differential #Diagnosis
Mycoses HISTOPLASMOSIS • Inhalation of conidia → Yeast → travel to lymph nodes → spread in body • Bird
pulmonary symptoms • Rheumatologic ... Pulmonary 3) Abdominal ... especially the CNS ... MC: CNS CSF: • ... osteoarticular, pulmonary, ocular
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