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The Stages of Syphilis 

Primary Syphilis 
- The chancre lesion is the hallmark of primary syphilis.
Primary Syphilis ... Without treatment ... - Late Latent ... - Late latent patients ... Syphilis - Late
Syphilis Staging - Primary, Secondary, Latent and Tertiary - Timing and Features

Primary syphilis classically presents with
Syphilis Staging ... - Primary, Secondary ... by condylomata lata ... into early and late ... infection and late
Syphilis - CDC 2021 Treatment Guidelines
Recommended Regimen:
 • Primary, secondary, and early latent: adults (including pregnant
Treatment Guidelines ... million units IM ... single dose • Late ... million units IM ... #Primary #Latent
Natural History of Syphilis
Primary - 2-6 weeks after infection
 • Chancre, Regional lymphadenopathy
Early Latent ≤ 1
Primary - 2-6 weeks ... 2 months after primary ... Hepatitis, Nephritis Late ... Latent - > 1 year ... Neurosyphilis → Late
Stages of Syphilis
Early Primary:
 • Painless chancre
 • Regional lymphadenopathy
Early Secondary:
 • Fever, malaise
 • Rash
Stages of Syphilis ... Early Primary: ... year of infection Late ... Late Latent: • ... BostonChiefs #Syphilis
Treatment of Syphilis
Early:
 • Penicillin G, 2.4 million units IM once OR
 • Doxycycline 100mg BID
Treatment of Syphilis ... million units IM ... BID for 2 weeks Late ... million units IM ... BostonChiefs #Syphilis
Syphilis - Clinical Manifestations and Treatment

1) Primary Syphilis
 • Direct lesion contact during sex is responsible
1) Primary Syphilis ... Albuminuria, nephrotic syndrome ... Syphilis: • Patient ... infection • Late ... • Late latent
Treatment Recommendations for Syphilis in Non-Pregnant Adults by Syphilis Stage

Incubating Infection, Primary, Secondary, Early Latent Syphilis:
Treatment Recommendations ... Incubating Infection, Primary ... day for 14 days Late ... CDC2015 #Regimen #Primary ... #Latent #Treatment
Secondary Syphilis Rash
Secondary syphilis is the most contagious of all the stages of this disease, and
with or without treatment ... , but without treatment ... progress to the latent ... and late stages ... lesions—Condyloma lata—on
Evaluation of Secondary Hypertension
 • Primary aldosteronism - PRA, PAC
 • Renal artery stenosis - Renal
Hypertension • Primary ... fT4 • Cushing syndrome ... - Late-night salivary ... Mineralocorticoid excess syndromes