16 results
Immune Reactions and Immunosuppressant Drugs

Glucocorticoids - Inhibition of cytokine synthesis, e.g., IL-1, IL-2
Muromonab-CD3 - Monoclonal antibody
Calcineurin
cytokine synthesis, e.g ... Immunosuppressant #Drugs #Pharmacology ... #Pathophysiology ... #immunology
Anaphylaxis: Signs and Symptoms
Anaphylaxis: when any egg of three conditions is met:
1. Acute onset of skin/mucosal
Anaphylaxis: when any egg ... occurrence of late ... Cardiac Compromise (e.g ... #Anaphylaxis #pathophysiology ... #immunology #diagnosis
Anaphylaxis: Treatments (Acute)
Additional Info:
 • IV steroids may be considered for prevention of late phase reactions.
prevention of late ... antagonist use (e.g ... adjunct therapy) e.g ... Treatments #Management #pathophysiology ... #immunology
Anti-IL6 Agents (Tocilizumab, Siltuximab) in COVID19

IL-6 activates T cells and macrophages, among other cell types (see
Siltuximab) in COVID19 ... Tocilizumab 4-8mg/kg ... be repeated 12h later ... Siltuximab 11mg/kg ... #Pharmacology #
EKG Interpretation Cheat Sheet
1) Rate 
 - Regular - Count-Off 
 - Irregular - Count number
EKG Interpretation ... Cheat Sheet 1) Rate ... in leads V1-3 (Right ... proportional to heart rate ... @AmyChung #EKG
The JT Interval and Pro-Arrhythmic Risk
Measured from the J-point to the end of the T-wave, the
- Right Bundle Branch ... with QRS ≥120 ms ... electrocardiogram #pathophysiology ... #ekg #ecg #cardiology
General schema for respiratory support in patients with COVID-19
Low flow nasal cannula
 • Typically set at
patients with COVID ... Iimitation in the flow rate ... severe hypoxemia might ... filter • N95 mask ... volumes of ~6 cc/kg
COVID-19 Intubation Checklist

Personal protective equipment (PPE)
 • Standard PPE
   • N95 or PAPR.
COVID-19 Intubation ... at least 1.2 mg/kg ... Continue with backup rate ... using BVM: Hold mask ... Care @iBookCC #COVID19
X-Linked Agammaglobulinemia: Pathogenesis and clinical findings
The epidemiology of this disease is 1/340,000 births and roughly double
roughly double this rate ... bacterial infections (e.g ... Agammaglobulinemia #XLinked #pathophysiology ... #immunology
Mask Oxygen Delivery Devices

Simple Mask aka Hudson's Mask:
 • Flow 6-10 LPM
 • FiO2 35-50%
Face Tent:
Mask Oxygen Delivery ... aka Hudson's Mask ... not tolerate a tight-fitting ... mask (e.g. facial ... specified flow rate