27 results
Necrotizing Soft Tissue Infection: Diagnostic Accuracy of Physical Examination, Imaging, and LRINEC ScoreA Systematic Review and
Necrotizing Soft Tissue Infection ... #Diagnosis #EBM ... LRINEC #Accuracy #Sensitivity ... #Specificity
Fernando SM et al. Prognostic Accuracy of the Quick Sequential Organ Failure Assessment for Mortality in
With Suspected Infection ... pubmed/29404582 #EBM ... Screening #Sepsis #Sensitivity ... #Specificity #Metaanalysis
CNS Infection in HIV / AIDS - Differential Diagnosis Framework

Principles of HIV-Associated CNS Opportunistic Infections:
 •
present in 15% of cases ... 100%, specificity ... Demyelinating disease caused ... effect/Edema • EBV ... 92% and specificity
Invasive Aspergillus (IA) - Diagnosis and Management
Aspergillus is ubiquitous in nature. Most invasive infections are caused
are caused by members ... Galactomannan sensitivity ... associated with low sensitivity ... and low specificity ... considered in certain cases
Guillain-Barre Syndrome - Summary

Acute AIDP that presents with rapidly progressive flaccid weakness

Epidemiology:
 • 1-2 cases/100,000 per
Guillain-Barre Syndrome ... Epidemiology: • 1-2 cases ... Pathophysiology ... response preceding infection ... - HIV, CMV, EBV
Bell's Palsy
Bell’s Palsy is a damage, acute weakness, or paralysis of the Facial nerve (7th CN),
an identifiable cause ... The cause is unknown ... associated with viral infections ...     - Epstein-Barr ... neurology #anatomy #pathophysiology
Childhood Immunization Schedule: Why we immunize
 • Diphtheria Toxin -> URT inflammation causes pseudomembrane with hardened
& seizures are late ... and hematologic infection ... widespread infection ... bacteremia are late ... peds #pediatrics #pathophysiology
Common Variable Immunodeficiency (CVID)

What?
CVID: Immunodeficiency disorder with hypogammaglobulinemia -> increased infection risk secondary to impaired B-cell
present in middle to late ... childhood and late ... disease • Infectious ... DDX - Other causes ... (Epstein-Barr syndrome
Guillain-Barré Syndrome (GBS)
Acute autoimmune demyelinating polyradiculoneuropathy that presents with rapidly progressive flaccid weakness
Epidemiology:
 • Incidence: 1
Guillain-Barré Syndrome ... Incidence: 1 to 2 cases ... to a preceding infection ... • Most common infection ... the underlying pathophysiology
Hemophagocytic Lymphohistiocytosis (HLH)
Pathophysiology: Triggering factor (infection,...)→Activation of CD8 T cells (IFN-y) → Excessive activation of macrophages
Lymphohistiocytosis (HLH) Pathophysiology ... Triggering factor (infection ... +++: Virus (EBV, ... biologics (CMV +++, EBV ... Drugs, Unknown cause