57 results
Necrotizing Soft Tissue Infection: Diagnostic Accuracy of Physical Examination, Imaging, and LRINEC ScoreA Systematic Review and
Necrotizing Soft Tissue Infection ... #Diagnosis #EBM ... LRINEC #Accuracy #Sensitivity ... #Specificity
Fernando SM et al. Prognostic Accuracy of the Quick Sequential Organ Failure Assessment for Mortality in
With Suspected Infection ... pubmed/29404582 #EBM ... Screening #Sepsis #Sensitivity ... #Specificity #Metaanalysis
Invasive Aspergillus (IA) - Diagnosis and Management
Aspergillus is ubiquitous in nature. Most invasive infections are caused
Diagnosis and Management ... are caused by members ... Galactomannan sensitivity ... and low specificity ... IA #Diagnosis #Management
CNS Infection in HIV / AIDS - Differential Diagnosis Framework

Principles of HIV-Associated CNS Opportunistic Infections:
 •
present in 15% of cases ... 100%, specificity ... Demyelinating disease caused ... effect/Edema • EBV ... 92% and specificity
Evidence supports the Ottawa ankle rules as an accurate instrument for excluding fractures of the ankle
instrument has a sensitivity ... 100% and a modest specificity ... #Diagnosis #Management ... #EM #Ortho #Sports
Childhood Immunization Schedule: Why we immunize
 • Diphtheria Toxin -> URT inflammation causes pseudomembrane with hardened
& seizures are late ... and hematologic infection ... widespread infection ... bacteremia are late ... peds #pediatrics #pathophysiology
Hemophagocytic Lymphohistiocytosis (HLH)
Pathophysiology: Triggering factor (infection,...)→Activation of CD8 T cells (IFN-y) → Excessive activation of macrophages
Lymphohistiocytosis (HLH) Pathophysiology ... +++: Virus (EBV, ... biologics (CMV +++, EBV ... Drugs, Unknown cause ... Lymphohistiocytosis #diagnosis #management
IDSA Algorithm for the Management of Purulent skin and soft tissue infections (SSTIs). 
Mild infection: for
Algorithm for the Management ... tachycardia (heart rate ... tachypnea (respiratory rate ... including those caused ... SSTIs #Algorithm #Management
Streptocccus Pneumoniae
Microbiology: Gram Positive, Alpha-hemolytic, Catalase Negative
Epidemiology - 10% adult carriers:
 • Most common cause of:
• Most common cause ... media • Important cause ... Sputum culture (Sensitivity ... 82%, Specificity ... microbiology #diagnosis #management
Common Variable Immunodeficiency (CVID)

What?
CVID: Immunodeficiency disorder with hypogammaglobulinemia -> increased infection risk secondary to impaired B-cell
present in middle to late ... childhood and late ... and M panel Management ... DDX - Other causes ... hematology #diagnosis #management