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diagnosis fungal betadglucan galactomannan infections infectiousdiseases management abscess aids biomarkers causes cns comparison dermatology falsepositives hiv immunology laboratory lung mycoses
1,3-Beta-D-Glucan and Galactomannan Testing Sensitivity Specificity and False Positives 1,3-Beta-D-Glucan • Cell wall component of many fungi
Galactomannan Testing ... Sensitivity Specificity ... 96% • Higher specificity ... >90% (In most clinical ... in BAL does not differentiate
Fungal Biomarkers: Beta-D-Glucan and Aspergillus Galactomannan Beta-D-Glucan: • Polysaccharide cell wall component of many fungi • Pathogens:
& Specificity: ... cut-offs defined in clinical ... & Specificity ... BAL GM does not differentiate ... Frozen ice-pops (in setting
CNS Infection in HIV / AIDS - Differential Diagnosis Framework Principles of HIV-Associated CNS Opportunistic Infections: •
in HIV / AIDS - Differential ... should be based on clinical ... effect/Edema • EBV ... of serum CrAg testing ... comparable to CSF testing
Lung Abscess - Diagnosis and Management Summary Lung Abscess Etiology: • Necrosis of lung parenchyma by a
Lung Abscess Pathophysiology ... Lung Abscess - Clinical ... Putrid sputum/sour-tasting ... in case of PCN allergy ... Lung Abscess Differential
Mycoses HISTOPLASMOSIS • Inhalation of conidia → Yeast → travel to lymph nodes → spread in body • Bird
antigen assay has a sensitivity ... and specificity ... Urinary antigen testing ... ASPERGILLOSIS • Aspergillus ... Aspergillosis Pathophysiology
Pathergy Summary Overview What is pathergy? Pathergy is an exaggerated skin injury occurring after minor trauma such as
Ulceration • Pathergy testing ... • 97% specificity ... and 92% sensitivity ... Pathergy #diagnosis #differential ... #allergy #immunology
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