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diagnosis differential causes diffuse lymphadenopathy chronic cll focal hemolytic localized lymphocytic mds monoclonal myelodysplasia myelodysplastic paraproteinemias syndromes testing
Causes of Diffuse and Localized Lymphadenopathy - Differential Diagnosis Algorithm • Reactive (Inflammatory / Infectious) •
Differential Diagnosis Algorithm ... • Neoplastic (Leukemia ... Lymphadenopathy #LAD ... #Causes #Hematology ... #Oncology
Causes of Diffuse Lymphadenopathy - Differential Diagnosis Algorithm Reactive: - Systemic Inflammatory •
Differential Diagnosis Algorithm ... Lymphadenopathy #LAD ... Differential #Diagnosis #Algorithm ... #Causes #Hematology ... #Oncology
Chronic Lymphocytic Leukemia - Summary Cancer affecting lymphocytes/Mature B cell neoplasm • Lymphocytes accumulate in large numbers
Chronic Lymphocytic Leukemia ... • Most common leukemia ... • Neutropenia, anemia ... #diagnosis #workup ... #oncology #hematology
Leukemias Overview: ALL, CML, AML, APML, CLL Acute leukemias > 20% blasts in the peripheral blood smear
Leukemias Overview ... Chronic leukemia ... activity • ↓ LAP ... - infiltrates (anemia ... #Hematology #Oncology
Hemolytic Anemia - Differential Diagnosis Algorithm • Sickle cells - Consider sickle cell disease (diverse genotypes):
Hemolytic Anemia ... Differential Diagnosis Algorithm ... nucleotidase deficiency, lead ... ARUPLabs #Hemolytic #Anemia ... #workup #hematology
Myelodysplastic Syndromes (MDS) What? Myelodysplastic syndromes are a group of disorders caused by blood cells that are poorly
formed or don’t work ... • Hairy Cell Leukemia ... Workup: • Complete ... Syndromes #diagnosis #hematology ... #oncology
Paraproteinemias Entities That Can Feature A Monoclonal Protein/M Component: • MM • WM • MGUS • MGCS • MGRS • Splenic Marginal Zone
Autoantibodies: • WAIHA • CAD ... (-) hemolytic anemia ... Thrombosis in vascular beds-renal ... Paraproteinemias #Hematology ... Differential #Diagnosis #Oncology
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