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diagnosis management infectiousdiseases differential american cardiology chagas chronic hematology leukemia lymphocytic oncology rheumatology trypanosomiasis candida candidemia cglabrata francisella fungal fungemia
Fever Patterns - Differential Diagnosis Framework Continuous Fever: Temp > 38°C with only 1 degree fluctuation in 24
Acute bacterial endocarditis ... • Infective endocarditis ... , malaria • Leptospira ... • Leptospirosis ... • Malaria • Leptospirosis
Endocarditis Summary Who? Infectious: • Pre-existing valvular disease • Prosthetic valve • Congenital heart disease • IV substance use • IV catheter • Recent
Endocarditis Summary ... Infectious: • Pre-existing ... Hypercoagulable (APLAS) Microbiology ... night sweats, fever ... Persistent bacteremia/fevers
Chronic Lymphocytic Leukemia - Summary Cancer affecting lymphocytes/Mature B cell neoplasm • Lymphocytes accumulate in large numbers
Lymphocytic Leukemia - Summary ... Lymphadenopathy • Fevers ... weeks without infection ... cells can indicate disease ... microglobulin Treatment
Hemophagocytic Lymphohistiocytosis (HLH) Pathophysiology: Triggering factor (infection,...)→Activation of CD8 T cells (IFN-y) → Excessive activation of macrophages
• Clinical: fever ... • Autoimmune diseases ... Adult-onset Still disease ... Unknown cause Treatment ... #summary #rheumatology
Tularemia - Diagnosis and Management Summary Francisella tularensis - Aerobic fastidious gram-negative Coccobacillus - Zoonotic Infection •
and Management Summary ... Coccobacillus - Zoonotic Infection ... Ulceroglandular: Fever ... : • Severe Disease ... infectiousdiseases #microbiology
Chronic Lymphocytic Leukemia (CLL) - Summary Overview: • Most common leukemia in adults • Disorder of
Lymphocytic Leukemia (CLL ... ) - Summary Overview ... ) B symptoms → fevers ... Complications: 1) Infection ... chemotherapy for low-risk disease
Chagas Disease (American trypanosomiasis) - Diagnosis and Management Summary Acute Chagas Disease (8-12 weeks): • Mild: Malaise,
and Management Summary ... Mild: Malaise, fever ... • Treatment: ... useful for chronic infection ... Diagnosis #Management #Microbiology
Mycoses HISTOPLASMOSIS • Inhalation of conidia → Yeast → travel to lymph nodes → spread in body • Bird
respiratory symptoms • Fever ... • Cough, fever ... • Isolated fever ... arthritis, and endocarditis ... Local Disease:
Fever After International Travel Infectious Disease: • Endemic in either the destination or home region Viral Syndromes: Arboviral infections, a
Disease: • Endemic ... as Ebola virus disease ... : • Leptospirosis ... during the U.S. summer ... Zika virus or leptospira
Endocarditis - Overview and Differential Diagnosis Framework Who? Infectious: • Pre-existing valvular disease • Prosthetic valve • Congenital heart disease • IV
Infectious: • Pre-existing ... Hypercoagulable (APLAS) Microbiology ... night sweats, fever ... hematuria, + RF Treatment ... Persistent bacteremia/fevers
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