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management rheumatology differential hemophagocytic hlh lymphohistiocytosis oncology approach arthritis chronic classification hemeonc joint leukemia lymphocytic lymphoma msk pain polychondritis relapsing
Chronic Lymphocytic Leukemia - Summary Cancer affecting lymphocytes/Mature B cell neoplasm • Lymphocytes accumulate in large numbers
lymphoma SLL ... Lymphadenopathy • Fevers ... Physical Exam/Signs ... #workup #oncology ... #hematology
Hodgkin's Lymphoma Overview Hodgkin's lymphoma (HL) is an uncommon hematological malignancy arising from mature B cells. It
• Dyspnea • Fever ... Lymphoma Workup ... through Ann Arbor criteria ... #lymphoma #diagnosis ... classification #hematology
Hemophagocytic Lymphohistiocytosis (HLH) Pathophysiology: Triggering factor (infection,...)→Activation of CD8 T cells (IFN-y) → Excessive activation of macrophages
• Clinical: fever ... Hemopathies+++: Hodgkin ... Autoimmune diseases: SLE ... Drugs, Unknown cause ... treatment #summary #rheumatology
Approach to Joint Pain - Diagnostic Framework 1) Chronicity 2) Inflammatory vs Non-Inflammatory 3) Number of Joints Involved 1) Chronicity:
to Joint Pain - Diagnostic ... acute rheumatic fever ... Like in this case ... Chronic = RA, SLE ... #approach #workup
Vasculitis - Differential Diagnosis Framework When to Consider Vasculitis: • Purpura, ischemic skin lesions • Mononeuritis multiplex • Hematuria, proteinuria,
diseases, such as SLE ... purpura: Strong sign ... CRP GCA (Giant Cell ... tract, and often causes ... #Rheumatology
Hemophagocytic Lymphohistiocytosis (HLH) High mortality without prompt recognition and management. HLH is a critical diagnostic consideration in
hyperinflammatory syndrome caused ... Presentation • Common Signs ... Diagnostic Criteria ... of 8 HLH-2004 criteria ... #Management #Hematology
Relapsing Polychondritis What is it? Recurrent inflammation of the cartilage in the body (Autoimmune disorder) Who? • Most frequently: 40
Males • Affects all ... Nonspecific symptoms: Fever ... and fatigue Criteria ... such as: • SLE ... #diagnosis #management
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