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management hlh lymphohistiocytosis rheumatology activation chronic cll differential hemeonc leukemia lymphocytic macrophage mas myelitis neurology oncology polychondritis relapsing summary syndrome
Macrophage Activation Syndrome (MAS) Classified among the secondary or acquired forms of haemophagocytic lymphohistiocytosis (sHLH) What? A subset of
erythematosus [SLE ... Histopathologic criteria ... Treatment: • Corticosteroids ... Activation #Syndrome #Diagnosis ... #Management #Hematology
Hemophagocytic Lymphohistiocytosis (HLH) Definition: Overwhelming clinical syndrome associated with excessive macrophage activation and cytokine storm due to
Hemophagocytic Lymphohistiocytosis ... : HLH signs and ... following: • Fever ... • Bicytopenia Treatment ... #hematology
Hemophagocytic Lymphohistiocytosis (HLH) Pathophysiology: Triggering factor (infection,...)→Activation of CD8 T cells (IFN-y) → Excessive activation of macrophages
Hemophagocytic Lymphohistiocytosis ... • Clinical: fever ... Autoimmune diseases: SLE ... Unknown cause Treatment ... #management #treatment
Hemophagocytic Lymphohistiocytosis (HLH) High mortality without prompt recognition and management. HLH is a critical diagnostic consideration in
Hemophagocytic Lymphohistiocytosis ... Presentation • Common Signs ... Diagnostic Criteria ... #HLH #Hemophagocytic ... #Management #Hematology
Chronic Lymphocytic Leukemia - Summary Cancer affecting lymphocytes/Mature B cell neoplasm • Lymphocytes accumulate in large numbers
non-Hodgkin lymphoma SLL ... Lymphadenopathy • Fevers ... Physical Exam/Signs ... microglobulin Treatment ... workup #oncology #hematology
Transverse Myelitis Overview Focal inflammatory disorder of the spinal cord resulting in rapid onset of weakness, sensory
Criteria: • Sensory ... • Bilateral signs ... Mycoplasma - Leptospirosis ... Disorders: - SLE ... Transverse Myelitis Treatment
Relapsing Polychondritis What is it? Recurrent inflammation of the cartilage in the body (Autoimmune disorder) Who? • Most frequently: 40
Nonspecific symptoms: Fever ... and fatigue Criteria ... cases such as: • SLE ... affected tissue Treatment ... #diagnosis #management
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