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oncology differential leukemia monoclonal pain ankle anorexianervosa approach arthritis causes chronic classification cll disease gammopathy injury lymphocytic mds mgus msk
Causes of Bone/Joint Pain in Sickle Cell Disease Vaso-occlusive pain: • Mechanism: ischemic pain • Can present
Causes of Bone/Joint ... other orthopedic complications ... #Joint #Pain #SickleCell ... #differential #diagnosis ... #causes #hematology
Approach to Joint Pain History: Is the pain from: • Joint • Adjacent bursa • Tendon • Ligament • Bone • Muscle • Referred from
• Tendon • Ligament ... • Bone • Muscle ... the subchondral bone ... #approach #workup ... #differential #diagnosis
Webber Ankle Injury Classification A: In a Supination-Adduction injury the fibula breaks first, with a fracture below
are broken the joint ... Because a deltoid ligament ... appear to be a stable ... one on a standard ... #Diagnosis #Orthopedics
Chronic Lymphocytic Leukemia - Summary Cancer affecting lymphocytes/Mature B cell neoplasm • Lymphocytes accumulate in large numbers
phenomenon CLL Diagnosis ... kinase (BTK) Complications ... Warm AIHA • Bone ... #workup #oncology ... #hematology
Complications of Monoclonal Gammopathy of Undetermined Significance (MGUS) Fracture, Osteoporosis - Increased osteoclast activity and bone resorption
Complications of ... Significance (MGUS) Fracture ... osteoclast activity and bone ... resorption - Bone ... #diagnosis #hematology
Leukemias Overview: ALL, CML, AML, APML, CLL Acute leukemias > 20% blasts in the peripheral blood smear
blood smear or on bone ... pain, fever, joint ... Transformation: • Complication ... #Leukemia #Hematology ... #Oncology #Diagnosis
Myelodysplastic Syndromes (MDS) What? Myelodysplastic syndromes are a group of disorders caused by blood cells that are poorly
formed or don’t work ... characteristic feature ... Workup: • Complete ... Myelodysplastic #Syndromes #diagnosis ... #hematology #oncology
Paraproteinemias Entities That Can Feature A Monoclonal Protein/M Component: • MM • WM • MGUS • MGCS • MGRS • Splenic Marginal Zone
Entities That Can Feature ... Splenic Marginal Zone ... Scleromyxedema (CNS+GI+CVS+joints ... Paraproteinemias #Hematology ... #Differential #Diagnosis
Anorexia Nervosa: Complications CARDIAC ABNORMALITIES - Functional: Low BP, Sinus bradycardia, prolonged QT interval - Structural: Reduced
and memory loss HEMATOLOGIC ... Osteoporosis - Low bone ... increased risk of fracture ... DERMATOLOGIC PRESENTATIONS ... pathophysiology #diagnosis
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