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The GFR Clock for Staging CKD

Staging CKD is most frequently done by calculating the estimated glomerular
The GFR Clock for ... function rate (eGFR ... calculating the eGFR ... Using the GFR clock ... #Nephro #CKD #EGFR
Interpreting Kidney Biomarkers

↑ Creatinine: 
 • AKI, CKD
 • Medications that lead to nephroprotective ↓ in
nephroprotective ↓ in GFR ... hyperthyroidism ↓ eGFR
ALBUMINURIA

•	Indicator of kidney damage and / or a biomarker of systemic diseases dates back to 1969,
formerly called "macroalbuminuria ... independent of eGFR ... cardiovascular #eGFR ... #AER #ACR #macroalbuminuria ... #microalbuminuria
To improve the usefulness of the serum creatinine concentration as a marker of kidney function, prediction
accurately predict GFR ... overestimation of GFR ... used to estimate GFR ... CockcroftGault #EGFR
Renal Failure Prognosis - The eGFR and proteinuria offers a general prognosis as demonstrated in the
Prognosis - The eGFR ... #CKD #EGFR #Proteinuria
Regulation of GFR
Physiologically, GFR is auto-regulated very precisely with changes in the mean arterial pressure (MAP)
Regulation of GFR ... Physiologically, GFR ... Pathophysiology #Nephrology #GFR
Definitions of AKI, CKD, AKD
Acute Kidney Injury (AKI):
 • Increase in SCr by 2 50% within
Disease (CKD): • GFR ... • AKI, OR • GFR ... • Decrease in GFR ... Disease (NKD): • GFR
Complications of CKD
 - Patients with stages 1-3 ([GFR] >30 mL/min) of CKD are generally asymptomatic;
with stages 1-3 ([GFR ... CKD stages 4-5 (GFR
Albuminuria (Grades) and Risk for CKD
Normal to mildly increased albuminuria:
 - Albumin excretion rate: < 30
albuminuria (formerly Microalbuminuria ... albuminuria (formerly Macroalbuminuria ... - Macroalbuminuria
Adjusted Pain Medication Dosing based on GFR

#Renal #Dosing #Pain #Pharmacology #Opiates #CKD #Gabapentin #Table
Dosing based on GFR