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oncology differential algorithm chronic cll lymphocytic management anemia aplastic bandemia cancer cbc compared comparison disorders eosinophil eosinophilia erythemas gap globulin
Chronic Lymphocytic Leukemia - Summary Cancer affecting lymphocytes/Mature B cell neoplasm • Lymphocytes accumulate in large numbers
Lymphadenopathy • Fevers ... Diagnosis: • ... ’s lymphoma or acute ... #diagnosis #workup ... #oncology #hematology
Leukemias Overview: ALL, CML, AML, APML, CLL Acute leukemias > 20% blasts in the peripheral blood smear
Acute leukemias ... Headaches, bone pain, fever ... Lymphadenopathy • HSM • Fevers ... #Hematology #Oncology ... #Diagnosis
Eosinophil Disorders Testing Algorithm INDICATIONS FOR TESTING: • Peripheral blood eosinophilia/hypereosinophilia uncovered incidentally during medical evaluation or
incidentally during medical ... evaluation or workup ... /µL Workup • Screen ... #Differential #diagnosis ... #hematology #eosinophilia
Aplastic Anemia - Illness Script Signs and symptoms: • Recurrent infections from neutropenia • Mucosal bleeding from
Consider stem cell ... if neutropenic fever ... progress to MDS or acute ... leukemia • Associated ... management #treatment #hematology
Chronic Lymphocytic Leukemia (CLL) - Summary Overview: • Most common leukemia in adults • Disorder of
Lymphocytes • Median ... minimal tumor burden Diagnosis ... ) B symptoms → fevers ... #oncology #hematology ... #hemeonc #diagnosis
Myelodysplastic Syndromes (MDS) What? Myelodysplastic syndromes are a group of disorders caused by blood cells that are poorly
formed or don’t work ... Leukemia • Idiopathic ... Workup: • Complete ... Myelodysplastic #Syndromes #diagnosis ... #hematology #oncology
Bandemia Overview Normal: < 1% Clinically significant: > 10% Band neutrophils are slightly less mature than segmented neutrophils and
Left Shift: • Cell ... Tissue damage • Leukemia ... tachycardia or fever ... count on initial evaluation ... neutrophil #WBC #CBC #hematology
Erythemas Summarized Erythema ab igne • A dermatosis that results from repeated exposure to heat (fires, heating
fires, heating pads ... children with acute ... multiforme • Acute ... #differential #diagnosis ... #dermatology #compared
Elevated Globulin - Protein Gap (Total Protein - Albumin > 4) Work-up of an Elevated Globulin Gap: •
Albumin > 4) Work-up ... first step in evaluation ... gastric tumors • Hematology ... #differential #diagnosis ... #hematology
Solitary Cell Plasmacytoma What? • Plasma cell neoplasms can present as a single lesion (solitary plasmacytoma) • In 3%
• Median age 50- ... Diagnosis? ... Evaluation? ... Prognosis: • Median ... #Workup #Hematology
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