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oncology differential management algorithm cancer leukemia apml chronic cll compared comparison differentiation disorders emergencies eosinophil eosinophilia erythemas gap globulin hemophagocytic
Chronic Lymphocytic Leukemia - Summary Cancer affecting lymphocytes/Mature B cell neoplasm • Lymphocytes accumulate in large numbers
Lymphadenopathy • Fevers ... Diagnosis: • ... ’s lymphoma or acute ... #workup #oncology ... #hematology
Eosinophil Disorders Testing Algorithm INDICATIONS FOR TESTING: • Peripheral blood eosinophilia/hypereosinophilia uncovered incidentally during medical evaluation or
incidentally during medical ... evaluation or workup ... /µL Workup • Screen ... #Differential #diagnosis ... #hematology #eosinophilia
Leukemias Overview: ALL, CML, AML, APML, CLL Acute leukemias > 20% blasts in the peripheral blood smear
Headaches, bone pain, fever ... develop leukostasis syndrome ... • Tumor lysis syndrome ... #Leukemia #Hematology ... #Oncology #Diagnosis
Differentiation Syndrome in APML Epidemiology: • Incidence: common in APL (2-48% depending on the study) • Triggers:
Differentiation Syndrome ... Release from blast cells ... • Induce blast cell ... : • Common: fever ... #management #hematology
Myelodysplastic Syndromes (MDS) What? Myelodysplastic syndromes are a group of disorders caused by blood cells that are poorly
Myelodysplastic Syndromes ... formed or don’t work ... Exposure to heavy metal ... Workup: • Complete ... #diagnosis #hematology
Oncologic Emergencies - Differential Diagnosis Framework HEMATOLOGIC ONCOLOGIC EMERGENCIES: Hyperviscosity Syndrome: • Spontaneous bleeding • Shortness of breath
- Differential Diagnosis ... Framework HEMATOLOGIC ... death Neutropenic Fever ... neutrophil count < 500 cells ... Hyperuricemia • Acute
Leukostasis vs Tumor Lysis Syndrome Leukostasis: • Pathophysiology: Large, immature blasts and high WBC count cause hyperviscosity
- 80% have fever ... - ACS, AKI, acute ... Lysis of tumor cells ... #TLS #diagnosis ... #management #hematology
Hemophagocytic Lymphohistiocytosis (HLH) Definition: Overwhelming clinical syndrome associated with excessive macrophage activation and cytokine storm due to
Overwhelming clinical syndrome ... presents as an acute ... following: • Fever ... Low or absent NK cell ... management #treatment #hematology
Pustular Skin Lesions - Differential Diagnosis Framework What are pustules? • Pustules < 5-10 mm + pus • Material
- Differential Diagnosis ... of inflammatory cells ... Pustules + Fever ... Acute generalized ... #Dermatology
Erythemas Summarized Erythema ab igne • A dermatosis that results from repeated exposure to heat (fires, heating
fires, heating pads ... children with acute ... multiforme • Acute ... #differential #diagnosis ... #dermatology #compared
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