2913 results
Causes of Lactate Elevation, Lactic Acidosis - Differential Diagnosis

The most common causes of hyperlactatemia are usually:
Causes of Lactate ... The most common causes ... - Many other causes ... Causes of Lactate ... and Toxins: - Metformin
Type B Lactic Acidosis
Elevated lactic acid when no systemic hypoperfusion is apparent
Causes:
 • Drugs (metformin, linezolid,
hypoperfusion is apparent Causes ... : • Drugs (metformin ... to clear) • D-lactate ... Lactic #Acidosis #causes
Metformin Associated Lactic Acidosis (MALA) 

Pathophysiology of MALA
 - Metformin interferes with the activity of the
Metformin Associated ... Pathophysiology of MALA - Metformin ... recycles peripheral lactate ... production  increased lactate ... Kat_Watson #MALA #Metformin
Lactic Acidosis Classification - Type A vs Type B
Type A Lactic Acidosis: Sepsis, Ischemic bowel, Hemorrhagic
Short bowel (D-lactate ... Renal failure, Metformin
Diabetes Combination Tablets - Estimated A1c Lowering 
Metformin + DPP4 
• Janumet (metformin + sitagliptin) 
•
A1c Lowering Metformin ... DPP4 • Janumet (metformin ... • Jentadueto (metformin ... • Kombiglyze (metformin ... saxagliptin) Metformin
Lactated Ringers (LR) vs Normal Saline (NS) - Comparison

Composition of LR:
 • Sodium 130 mEq/L
 •
Lactated Ringers ... mEq/L • Sodium lactate ... mEq • Sodium Lactate ... shift • Saline Causes ... • Saline May Cause
GOLDMARK - Mnemonic for Anion Gap Metabolic Acidosis
G - Glycols
O - Oxoproline
L - L-Lactate
D - D-Lactate
M
Oxoproline L - L-Lactate ... D - D-Lactate ... #differential #causes
Crystalloid Composition - Normal Saline, Ringer's Lactate, Hartmann's Solution, PlasmaLyte

Ca2+ Mg2+ Cl- 
Acetate 
Lactate 
Gluconate 
Bicarbonate
Saline, Ringer's Lactate ... Ca2+ Mg2+ Cl- Acetate ... Lactate Gluconate ... #LR #Ringers #Lactated
Causes of Vitamin B12 Deficiency - Cobalamin
Decreased Intake
Pancreas: Insufficiency
Intestine: SIBO, Celiac disease, IBD, Lymphoma, Amyloidosis, Resection,
Causes of Vitamin ... , H2 blockers, metformin ... differential #diagnosis #causes
Metformin 
Current Renal Dose Adjustments due to Risk of Lactic Acidosis 
> 60 No adjustment 
45-60
Metformin Current ... already taking metformin ... /ambcarerx #Metformin