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Metformin Associated Lactic Acidosis (MALA) Pathophysiology of MALA - Metformin interferes with the activity of the
Metformin Associated ... Pathophysiology of MALA - Metformin ... recycles peripheral lactate ... production  increased lactate ... Kat_Watson #MALA #Metformin
Causes of Lactate Elevation, Lactic Acidosis - Differential Diagnosis The most common causes of hyperlactatemia are usually:
Causes of Lactate ... The most common causes ... / hypoxemia -> focus ... Causes of Lactate ... and Toxins: - Metformin
Lactic Acidosis Classification - Type A vs Type B Type A Lactic Acidosis: Sepsis, Ischemic bowel, Hemorrhagic
Short bowel (D-lactate ... Renal failure, Metformin
Lactated Ringers (LR) vs Normal Saline (NS) - Comparison Composition of LR: • Sodium 130 mEq/L •
Lactated Ringers ... mEq/L • Sodium lactate ... mEq • Sodium Lactate ... shift • Saline Causes ... • Saline May Cause
GOLDMARK - Mnemonic for Anion Gap Metabolic Acidosis G - Glycols O - Oxoproline L - L-Lactate D - D-Lactate M
Oxoproline L - L-Lactate ... D - D-Lactate ... #differential #causes
Causes of Vitamin B12 Deficiency - Cobalamin Decreased Intake Pancreas: Insufficiency Intestine: SIBO, Celiac disease, IBD, Lymphoma, Amyloidosis, Resection,
Causes of Vitamin ... , H2 blockers, metformin ... differential #diagnosis #causes
Intraoperative Sepsis - Guidelines for Crises in Anaesthesia Severe sepsis (hypotension persisting after initial fluid challenge of
30ml.kg-1 or blood lactate ... likely underlying cause ... including blood gas, lactate ... devices could have caused ... Check serial lactates
Lactic Acidosis - Classification and Differential Diagnosis Type A Lactic Acidosis: Inadequate Oxygen Delivery • Anaerobic muscular
Fructose, Isoniazid, Lactate-based ... dialysate, Metformin ... #TypeA #TypeB #lactate
Lactic Acidosis - Differential Diagnosis Framework Type A: Impaired O2 Delivery (DO2) • Decreased O2 Delivery: Hypotension
Acid, Biguanides (Metformin ... with negative lactate ... requires separate D-lactate ... sugars into D-Lactate ... #criticalcare #lactate
Considerations for Crystalloids - 0.9% NS vs LR vs Plasma-Lyte - Causes hyperkalemia? - Safe to
Plasma-Lyte - Causes ... - Causes lactic ... - Serum lactate ... - Can cause a NAGMA
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