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Metformin Associated Lactic Acidosis (MALA) Pathophysiology of MALA - Metformin interferes with the activity of the
Metformin Associated ... recycles peripheral lactate ... production  increased lactate ... anaerobic metabolism Diagnosis ... Toxicity #Toxicology #Diagnosis
Lactic Acidosis Classification - Type A vs Type B Type A Lactic Acidosis: Sepsis, Ischemic bowel, Hemorrhagic
Short bowel (D-lactate ... Renal failure, Metformin ... #TypeA #TypeB #diagnosis
Lactic Acidosis - Classification and Differential Diagnosis Type A Lactic Acidosis: Inadequate Oxygen Delivery • Anaerobic muscular
and Differential Diagnosis ... Fructose, Isoniazid, Lactate-based ... dialysate, Metformin ... #Differential #Diagnosis ... #TypeA #TypeB #lactate
Lactic Acidosis - Differential Diagnosis Framework Type A: Impaired O2 Delivery (DO2) • Decreased O2 Delivery: Hypotension
- Differential Diagnosis ... Acid, Biguanides (Metformin ... with negative lactate ... Difficult to diagnosis ... #Differential #Diagnosis
Causes of Lactate Elevation, Lactic Acidosis - Differential Diagnosis The most common causes of hyperlactatemia are usually:
Causes of Lactate ... - Differential Diagnosis ... laboratory or diagnostic ... and Toxins: - Metformin ... #Differential #Diagnosis
Type B Lactic Acidosis Elevated lactic acid when no systemic hypoperfusion is apparent Causes: • Drugs (metformin, linezolid,
Causes: • Drugs (metformin ... to clear) • D-lactate ... #differential #diagnosis
Diabetes Combination Tablets - Estimated A1c Lowering Metformin + DPP4 • Janumet (metformin + sitagliptin) •
A1c Lowering Metformin ... DPP4 • Janumet (metformin ... • Jentadueto (metformin ... • Kombiglyze (metformin ... saxagliptin) Metformin
Crystalloid Composition - Normal Saline, Ringer's Lactate, Hartmann's Solution, PlasmaLyte Ca2+ Mg2+ Cl- Acetate Lactate Gluconate Bicarbonate
Saline, Ringer's Lactate ... Ca2+ Mg2+ Cl- Acetate ... Lactate Gluconate ... #LR #Ringers #Lactated
Metformin Current Renal Dose Adjustments due to Risk of Lactic Acidosis > 60 No adjustment 45-60
Metformin Current ... already taking metformin ... /ambcarerx #Metformin
Lactated Ringers (LR) vs Normal Saline (NS) - Comparison Composition of LR: • Sodium 130 mEq/L •
Lactated Ringers ... mEq/L • Sodium lactate ... pH of 4-7.5 Lactated ... mEq • Sodium Lactate ... mole/L of sodium lactate
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