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diagnosis differential management pharmacology diabetes algorithm endocrinology nephrology treatment acidosis clinical classification chronic lactic dermatology medications rheumatology comparison diarrhea neurology
Diabetes Combination Tablets - Estimated A1c Lowering Metformin + DPP4 • Janumet (metformin + sitagliptin) •
A1c Lowering Metformin ... DPP4 • Janumet (metformin ... • Jentadueto (metformin ... saxagliptin) Metformin ... Tablets #Oral #DM2
Metformin Pharmacology Summary Mechanisms of Action: • Suppresses gluconeogenesis by the liver • Increases insulin-mediated glucose utilization
Metformin Pharmacology ... agent • Does not cause ... e.g. diarrhea, nausea ... EricsMedicalLectures/ #Metformin ... Pharmacology #Summary #DM2
Metformin Associated Lactic Acidosis (MALA) Pathophysiology of MALA - Metformin interferes with the activity of the
Metformin Associated ... Pathophysiology of MALA - Metformin ... recycles peripheral lactate ... production  increased lactate ... Kat_Watson #MALA #Metformin
Causes of Lactate Elevation, Lactic Acidosis - Differential Diagnosis The most common causes of hyperlactatemia are usually:
Causes of Lactate ... The most common causes ... - Many other causes ... Causes of Lactate ... and Toxins: - Metformin
Diabetes Type 2 Medication Management and Titration Algorithm - First line therapy is metformin and comprehensive lifestyle
line therapy is metformin ... CKD #Diabetes #DM2
Metformin - First Line Treatment for Diabetes Type 2 • Start with initial dose of 500 mg
Metformin - First ... medication #Metformin ... Pharmacology #Diabetes #DM2
Type 2 Diabetes - Screening, Diagnosis and Management Algorithm Lifestyle Modifications (Diet and Exercise) -> Start
Hypoglycemic (First Line: Metformin ... relative with DM2 ... associated with DM ... • Secondary Causes ... Management #algorithm #DM2
Lactic Acidosis Classification - Type A vs Type B Type A Lactic Acidosis: Sepsis, Ischemic bowel, Hemorrhagic
Short bowel (D-lactate ... Renal failure, Metformin
Diabetes Medications Summary Table Insulin Lifestyle modifications Metformin Sulfonylureas GLP-1 receptor agonists - ↓ major adverse CV events TZDs DPP-4 inhibitors SGLT2 inhibitors -
modifications Metformin ... endocrinology #dm2
Lactated Ringers (LR) vs Normal Saline (NS) - Comparison Composition of LR: • Sodium 130 mEq/L •
Lactated Ringers ... mEq/L • Sodium lactate ... mEq • Sodium Lactate ... shift • Saline Causes ... • Saline May Cause
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