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Metformin Associated Lactic Acidosis (MALA) Pathophysiology of MALA - Metformin interferes with the activity of the
Metformin Associated ... Pathophysiology of MALA - Metformin ... recycles peripheral lactate ... production  increased lactate ... Toxicology #Diagnosis #Management
Lactic Acidosis Classification - Type A vs Type B Type A Lactic Acidosis: Sepsis, Ischemic bowel, Hemorrhagic
Short bowel (D-lactate ... Renal failure, Metformin
Diabetes Combination Tablets - Estimated A1c Lowering Metformin + DPP4 • Janumet (metformin + sitagliptin) •
A1c Lowering Metformin ... DPP4 • Janumet (metformin ... • Jentadueto (metformin ... • Kombiglyze (metformin ... saxagliptin) Metformin
Metformin in Diabetic Kidney Disease Immediate release: • Initial 500 mg or 850 mg once daily •
Metformin in Diabetic ... eGFR < 30: Stop metformin ... do not initiate metformin ... annually if on metformin ... pharmacology #algorithm #management
Crystalloid Composition - Normal Saline, Ringer's Lactate, Hartmann's Solution, PlasmaLyte Ca2+ Mg2+ Cl- Acetate Lactate Gluconate Bicarbonate
Saline, Ringer's Lactate ... Ca2+ Mg2+ Cl- Acetate ... Lactate Gluconate ... #LR #Ringers #Lactated
Diabetes Type 2 Medication Management and Titration Algorithm - First line therapy is metformin and comprehensive lifestyle
Type 2 Medication Management ... line therapy is metformin ... Type2 #Medication #Management
Causes of Lactate Elevation, Lactic Acidosis - Differential Diagnosis The most common causes of hyperlactatemia are usually:
Causes of Lactate ... categories Lactate ... The use of lactate ... With ↑ Lactate ... and Toxins: - Metformin
Lactic Acidosis - Classification and Differential Diagnosis Type A Lactic Acidosis: Inadequate Oxygen Delivery • Anaerobic muscular
Fructose, Isoniazid, Lactate-based ... dialysate, Metformin ... #TypeA #TypeB #lactate
Metformin Current Renal Dose Adjustments due to Risk of Lactic Acidosis > 60 No adjustment 45-60
Metformin Current ... already taking metformin ... /ambcarerx #Metformin
Lactated Ringers (LR) vs Normal Saline (NS) - Comparison Composition of LR: • Sodium 130 mEq/L •
Lactated Ringers ... mEq/L • Sodium lactate ... pH of 4-7.5 Lactated ... mEq • Sodium Lactate ... mole/L of sodium lactate
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