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diagnosis management differential pharmacology diabetes clinical endocrinology algorithm pathophysiology causes treatment nephrology cardiology acidosis medications classification table comparison physicalexam antibiotics
Metformin Pharmacology Summary Mechanisms of Action: • Suppresses gluconeogenesis by the liver • Increases insulin-mediated glucose utilization
Metformin Pharmacology ... mL/minute/1.73 m2 ... about causing lactic ... EricsMedicalLectures/ #Metformin ... Pharmacology #Summary #DM2
Diabetes Combination Tablets - Estimated A1c Lowering Metformin + DPP4 • Janumet (metformin + sitagliptin) •
A1c Lowering Metformin ... DPP4 • Janumet (metformin ... • Jentadueto (metformin ... saxagliptin) Metformin ... Tablets #Oral #DM2
Lactic Acidosis Classification - Type A vs Type B Type A Lactic Acidosis: Sepsis, Ischemic bowel, Hemorrhagic
Lactic Acidosis ... Type B Type A Lactic ... Cardiogenic shock Type B Lactic ... Renal failure, Metformin ... transcriptases, Linezolid #Lactic
Metformin Current Renal Dose Adjustments due to Risk of Lactic Acidosis > 60 No adjustment 45-60
Metformin Current ... due to Risk of Lactic ... already taking metformin ... /ambcarerx #Metformin
Kussmaul Breathing in Lactic Acidosis Acute non-cardiopulmonary dyspnoea. 70 ys, DM, vomiting and URQ abdominal pain since
Kussmaul Breathing in Lactic ... dyspnoea. 70 ys, DM ... BGA: severe lactic ... regularly taken metformin
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 Diabetes Type 2 Medication Management and Titration Algorithm - First line therapy is metformin and comprehensive lifestyle
line therapy is metformin ... CKD #Diabetes #DM2
Metformin - First Line Treatment for Diabetes Type 2 • Start with initial dose of 500 mg
Metformin - First ... medication #Metformin ... Pharmacology #Diabetes #DM2
Metformin Associated Lactic Acidosis (MALA) Pathophysiology of MALA - Metformin interferes with the activity of the
Metformin Associated ... Lactic Acidosis ... Pathophysiology of MALA - Metformin ... concentrations > 5 μg/mL, metformin ... Kat_Watson #MALA #Metformin
Anion Gap Metabolic Acidosis • Diabetic Ketoacidosis ± Hyperglycemia ± Hyperosmolar • Alcoholic Ketoacidosis ± Hyperglycemia
glycol • Type B lactic ... Drugs ( Albuterol, Metformin
Diabetes Medications Summary Table Insulin Lifestyle modifications Metformin Sulfonylureas GLP-1 receptor agonists - ↓ major adverse CV events TZDs DPP-4 inhibitors SGLT2 inhibitors -
modifications Metformin ... endocrinology #dm2
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