36 results
Acute promyelocytic leukemia (blood). Typical morphologic features are bilobed ("butterfly") nuclei with dispersed chromatin, subtle to
Typical morphologic ... I see all of these ... features in most cases ... #APML #Pathology ... #Hematology #Clinical
Liver Enzymes (LFTs) - Causes of Hepatocellular and Cholestatic Liver Injury
Hepatocellular Liver Injury
 • AST/ALT elevation
Enzymes (LFTs) - Causes ... Injury • AST/ALT ... elevation > Alk ... specific for hepatic pathology ... Transaminitis #diagnosis
Reflex Testing - Causes of Hyporeflexia and Hyperreflexia
Focal Hyporeflexia: 
 • Radiculopathy, Mononeuropathy, Polyneuropathy, Acute stroke,
polyneuropathy (e.g ... injury, Early ALS ... Eclampsia, Late ALS ... #differential #diagnosis ... #table #neurology
Low Alkaline Phosphatase - Hypophosphatasia 

Is Low Alkaline Phosphatase Of Clinical Importance?

ALP enzyme- Discovered in 1923
Low
Most cases diagnosed ... collection with EDTA Pathophysiology ... respiratory failure • Neurologic ... Phosphatase: • Other causes ... Hyophosphatasia #hepatology
Causes of Thrombocytopenia and Platelet Disorders - Differential Diagnosis and Workup
History:
 - Prior platelet count, family
- Differential Diagnosis ... function test, ANA (e.g ... (CVID, WAS), (neurologic ... not required in all ... #hematology
Peripheral blood findings in microangiopathic hemolytic anemia.  DIC is a clinical and laboratory diagnosis, not
and laboratory diagnosis ... , not a morphologic ... conditions such as ... hemolytic #anemia #Hematology ... #Pathology #Smear
Acute Fatty Liver of Pregnancy (AFLP)
Pathophysiology:
 • Defect in fetal free fatty acid metabolism products →
) Pathophysiology ... = nonspecific (nausea ... Findings: • ↑AST/ALT ... ) Differential Diagnosis ... Liver #Pregnancy #hepatology
THE LIMPING OR NON-WEIGHT BEARING CHILD PATHWAY

RED FLAGS - In all cases there are specific
markers which
RED FLAGS - In all ... cases there are ... splenomegaly, abnormal neurology ... , back pain Haematology ... Peds #Pediatrics #Diagnosis
Amyotrophic Lateral Sclerosis (ALS) Summary
ALS: combination of the clinical examination finding of amyotrophy with the pathologic
Lateral Sclerosis (ALS ... ) Summary ALS: combination ... amyotrophy with the pathologic ... lateral sclerosis Pathophysiology ... Lateral #Sclerosis #neurology
Primary Biliary Cirrhosis (PBC) - Summary

PBC Epidemiology:
 • Female:Male 9:1
 • Common European descent
 • Age:
65 years PBC Pathophysiology ... intralobular bile ducts causes ... Nucleotidase • ALT ... obstruction • ALP ... #workup #hepatology