6 results
Causes of Abnormal PT and/or aPTT
Prolonged Prothrombin Time (PT)
1. Acquired deficiency of FVII
Abnormal PT and/or aPTT ... typically prolong aPTT ... alone but typically ... Causes #diagnosis #differential ... #hematology #coagulation
Platelet disorders and Aggregometry
Glanzmann Thrombasthenia
 • Defective aggregation to all agonists except ristocetin
 • Normal platelet,
platelet, PT, PTT ... count and platelet morphology ... 1 or Type 3) — differentiate ... considered first-line ... #hemepath #differential
Red Blood Cell (RBC) Morphology
Microcytic RBC: Pyridoxine deficiency, Thalassemia, Iron deficiency anemia, Chronic disease anemia (sometimes),
Blood Cell (RBC) Morphology ... Chemotherapy (e.g ... #differential # ... diagnosis #hematology ... #microscopy #atlas
Endocarditis Summary

Who?
Infectious:
• Pre-existing valvular disease
• Prosthetic valve
• Congenital heart disease
• IV substance use
• IV catheter
• Recent
Endocarditis Summary ... Hypercoagulable (APLAS ... Marantic (NTBE) Differential ... ↑ ESR, CRP • EKG ... #diagnosis #management
Postpartum Hemorrhage - Differential Diagnosis and Management 
Uterine Atony (80%) - Most PPH Will respond to
Postpartum Hemorrhage - Differential ... Diagnosis and Management ... respond to first line ... fibrinogen, PT/PTT ... #Diagnosis #Management
Invasive Aspergillus (IA) - Diagnosis and Management
Aspergillus is ubiquitous in nature. Most invasive infections are caused
Diagnosis and Management ... immunosuppression (eg ... Endophthalmitis, Endocarditis ... Non-pigmented (hyaline ... sometimes have this morphology