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Mucorales (Mucormycosis) - Fungal Pathology 

Ribbon-like hyphae with right angle branching, rare septations — mucorales

UCSD Internal
Mucorales (Mucormycosis ... rare septations — mucorales ... Medicine @ucsdim #mucorales
Invasive fungal infections: Morphology, Risk Factors, Disease Characteristics, Diagnostic Tools, First-Line Treatment
Aspergillus, Mucorales, P. Jiroveci, Cryptococcus,
Aspergillus, Mucorales
Morphology and Descriptions of Fungal Infections with Hyphae or Pseudohyphae in Tissues
Yeasts with Pseudohyphae: 
 •
Mucorales genera ... Consistent with Mucorales
Spectrum of activity for systemic antifungal agents
Antifungals: 5FC, flucytosine; AMB, amphotericin B; ANI, anidulafungin; CAS, caspofungin;
Cryptococcus neoformans, Mucorales
Common Fungal Pathology 
 • Candida - Small yeast intermingled with pseudohyphae
 • Aspergillosis - Septate
conidial heads • Mucorales
Mucor spp.
Characteristic of Mucor spp. isolates vs other Mucorales - absence of rhizoids, very long hyphae.
This
isolates vs other Mucorales
Fungal Biomarkers: Beta-D-Glucan and Aspergillus Galactomannan
Beta-D-Glucan:
 • Polysaccharide cell wall component of many fungi
 • Pathogens:
Cryptococcus, Mucorales ... - Negative: Mucorales
Proptosis - Differential Diagnosis - Unilateral vs Bilateral
Unilateral:
 • Infections (can become bilateral with cavernous sinus
Paranasal sinus mucoceles
Morphology and Descriptions of Endemic Fungal Infections with Yeasts in Tissues
Broad-based budding yeasts:
 • Description: Broad-based
Mucorales genera ... Consistent with Mucorales
Rhizopus spp on Culture and Microscopy
A "respiratory" specimen from a recently deceased organ donor.
This organ donor
spp. one of the Mucorales