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Multi-System Inflammatory Syndrome in Children (MIS-C) vs. Kawasaki Disease
CDC Case Definition for MIS-C;
 • < 21
Multi-System Inflammatory
Pediatric Inflammatory Multisystem Syndrome Temporally associated with SARS-CoV-2 infection (PIMS-TS)
Clinical features
all: fever > 101.3 F
most: oxygen
Pediatric Inflammatory Multisystem Syndrome Temporally associated with SARS-CoV-2 infection (PIMS-TS) Clinical features all: fever > 101.3 F most: oxygen requirement, hypotension some: abdominal pain, diarrhea, vomiting, conjunctivitis, cough, rash, sore throat, swollen hands / feet, lymphadenopathy, mucus membrane changes, syncope, neck swelling #Pediatrics #Multisystem #Inflammatory #Syndrome #PIMSTS #covid19 #sarscov2 #coronavirus #diagnosis #Signs #Symptoms
Pediatric Inflammatory Multisystem Syndrome Temporally associated with SARS-CoV-2 infection (PIMS-TS)

#PIMSTS #Pediatrics #Inflammatory #Multisystem #Syndrome #Peds #Signs
Pediatric Inflammatory Multisystem Syndrome Temporally associated with SARS-CoV-2 infection (PIMS-TS) #PIMSTS #Pediatrics #Inflammatory #Multisystem #Syndrome #Peds #Signs #Symptoms #Diagnosis
Systemic Sclerosis (Scleroderma)
Multi-system autoimmune disease characterized by vasculopathy and progressive fibrosis of skin and internal organs
3
Systemic Sclerosis ... (Scleroderma) Multi-system ... Limited cutaneous systemic ... knees • Diffuse systemic ... and/or trunk • Systemic
Necrotizing Fasciitis: Note the extensive edema, erythema, bullae formation, and necrosis in this patient's thigh. At
hypotensive with multi ... system organ failure
Secondary Causes of Hypothermia - Differential Diagnosis Framework

Definition:
- Core temp < 35°C

Infectious:
 - Sepsis

Neuromuscular Disease:
 -
insufficiency - Multi-system
Secondary Causes of Hypertension - Differential Diagnosis Algorithm
Hypertension - BP > 140/90 (>130/80 for DM)
Hypertensive urgency
hypertension (multi-drug ... Sympathetic nervous system
Multiple Myxomas on POCUS Echocardiogram

Apical 4-chamber view demonstrating multiple myxomas in a case of Carney complex
complex (a rare multi-system
Paraproteinemias

Entities That Can Feature A Monoclonal Protein/M Component:
• MM
• WM
• MGUS
• MGCS
• MGRS
• Splenic Marginal Zone
clubbing Clarkson/Systemic ... neuropathy) • Systemic ... zone lymphoma Multi-System
Gonorrhea: Pathophysiology

 - Neonatal Transmission -> Direct contact of patient mucosa with mother's infected mucosa while
cleared from host Multi-factorial ... of complement system