20 results
Alzheimer’s Disease: Pathogenesis and Clinical Findings
Risk factor for Late Onset Alzheimer's (99% of cases):
 - Increasing
Alzheimer's (99% of cases ... Motor dysfunction: myoclonic ... incontinence, apraxia ... AlzheimersDisease #Dementia ... #pathophysiology
Anticonvulsants as Mood Stabilizers: Mechanism and Side-effect
Examples: Valproate, Carbamazepine, Lamotrigine
 • Mild anticholinergic effect -> Drowsiness
Dose-dependent tremor, ataxia ... dizziness, diplopia, ataxia ... Systemic effect -> Nausea ... #SideEffects #Pathophysiology ... #Psychiatry #Pharmacology
Causes of B12 deficiency. 

This great diagram shows normal absorption and outlines most possible causes. At
Causes of B12 deficiency ... most possible causes ... the top is a B12-deficient ... transported into the blood ... #Diagnosis #Pathophysiology
Thiamine Deficiency - Differential Diagnosis Framework and Clinical Manifestations

Causes of Thiamine Deficiency:
 • Poor intake:
	- Diets
Manifestations Causes ... increase venous blood ... Ophthalmoplegia - Ataxia ... vascular contraction, blood ... beriberi #nutrition #pathophysiology
Widened Pulse Pressure - Differential Diagnosis and Pathophysiology

Pulse pressure is the difference between the systolic blood
Diagnosis and Pathophysiology ... Physiologic Causes ... Pathologic Causes ... • Severe iron deficiency ... Differential #Diagnosis #Pathophysiology
The Inhibited Pathway caused by N2O, leading to a decrease in the active form of Vitamin
Inhibited Pathway caused ... effects including ataxia ... use of N2O can cause ... with vitamin B12 deficiency ... #Pathophysiology
Central Retinal Artery Occlusion: Pathogenesis and clinical findings
 • Inflammatory Disease: (i.e. GCA, SLE, GPA) ->
Protein C & S deficiency ... , ATIII deficiency ... ) -> Increased blood ... retinal edema caused ... Occlusion #CRAO #pathophysiology
Features of a Sickle Cell Crisis 
Sickle-cell disease - an autosomal recessive blood disorder.
Characterized by red
autosomal recessive blood ... go on to block blood ... Crises can be precipitated ... The underlying pathophysiology ... co-existent G6PD deficiency
HIV-Associated Neurocognitive Disorder (HAND)

Definition:
HIV-Associated Neurocognitive disorders categories:
• Asymptomatic neurocognitive impairment
• Mild neurocognitive impairment
• HIV dementia

Pathophysiology:
HIV frequently
impairment • HIV dementia ... Pathophysiology ... integrity of the blood-brain ... penetrance through the blood-brain ... motor slowing and ataxia
Low Alkaline Phosphatase - Hypophosphatasia 

Is Low Alkaline Phosphatase Of Clinical Importance?

ALP enzyme- Discovered in 1923
Low
Most cases diagnosed ... • Vitamin C deficiency ... • blood collection ... with EDTA Pathophysiology ... Phosphatase: • Other causes