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aiha autoimmune blood differential management oncology product reactions workup agglutinin cell cold disease monoclonal paraproteinemias pathophysiology plasmacytoma solitary table thromboticthrombocytopenicpurpura
Autoimmune Hemolytic Anemia (AIHA) Pathophysiology - Warm vs Cold AIHA Warm AIHA: - 70%; IgG mediated -
Autoimmune Hemolytic ... Anemia (AIHA) Pathophysiology ... C3 positive or negative ... #Anemia #Pathophysiology ... #diagnosis #hematology
Autoimmune Hemolytic Anemia (AIHA) - Differential Diagnosis Table Warm AIHA (48-70%) Cold AHA (16-32%) • Donath-Landsteiner HA (paroxysmal
Autoimmune Hemolytic ... Anemia (AIHA) - ... Differential Diagnosis ... AIHA (7-8%) DAT-negative ... #Table #hematology
TTP - Laboratory Evaluation for Thrombotic Thrombocytopenic Purpura Activity of von Willebrand factor-cleaving protease activity - A
activity is the diagnostic ... result in severe anemia ... antiglobulin tests - Negative ... anemia Indirect ... #Workup #Hematology
Cold Agglutinin Disease 3 Types of Cold Sensitive Antibodies: 1. Cold Agglutinins (CAD) 2. Donath-Landsteiner
• Symptoms of anemia ... Diagnosis: • hemolytic ... anemia • Cold ... for anti-C3d and negative ... #anemia #hematology
Blood Transfusion Reactions Immune Mediated: • Febrile Non-Hemolytic Transfusion Reaction (FNHTR): Most common immune reaction to transfusion.
antigens (often false negative ... (rare), false negatives ... infographic by Nick ... #Transfusion #diagnosis ... #management #hematology
Blood Product Transfusions One Pager Summary Type and screen - determines blood type and detects in recipient
antigens (often false negative ... (rare), false negatives ... in 650,000 by Nick ... #Transfusions #diagnosis ... #management #hematology
Paraproteinemias Entities That Can Feature A Monoclonal Protein/M Component: • MM • WM • MGUS • MGCS • MGRS • Splenic Marginal Zone
• Coombs (-) hemolytic ... anemia due to cold ... Thrombosis in vascular beds-renal ... Paraproteinemias #Hematology ... #Differential #Diagnosis
Solitary Cell Plasmacytoma What? • Plasma cell neoplasms can present as a single lesion (solitary plasmacytoma) • In 3%
in the head and neck ... EMP - head and neck ... marrow biopsy negative ... • No CRAB - no anemia ... #Workup #Hematology
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