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coagulation differential syndrome abnormal prolonged pt rheumatology treatment activation blood clinical dic disorders disseminated essential et gangrenosum hemophilia intravascular leukostasis
Differential Diagnosis for a Prolonged PT and aPTT If the PT and the aPTT are both prolonged,
Differential Diagnosis ... Prolonged PT and aPTT ... the PT and the aPTT ... #diagnosis #differential ... #hematology #coagulation
Causes of Abnormal PT and/or aPTT Prolonged Prothrombin Time (PT) 1. Acquired deficiency of FVII
Causes of Abnormal ... Pre-analytical cause ... #Prolonged #Causes ... #diagnosis #differential ... #hematology #coagulation
Causes of Thrombocytopenia and Platelet Disorders - Differential Diagnosis and Workup History: - Prior platelet count, family
- Differential Diagnosis ... : INR/PT, aPTT(liver ... function test, ANA (e.g ... #Differential #Diagnosis ... #hematology
Hemophilia - Diagnosis and Management Diagnosis: • Consistent bleeding history (unless screening for disease in family members
established disease) • aPTT ... mixing study (aPTT ... normal in mild cases ... hemophilia type (e.g ... #hematology
Disseminated Intravascular Coagulation (DIC) Overview Increased Clotting and Consumption of Clotting Factors Findings: • Bleeding • Recent history
Treat primary cause ... INR < 2.3 - APTT ... #Coagulation #diagnosis ... #causes #treatment ... #management #hematology
Macrophage Activation Syndrome (MAS) Classified among the secondary or acquired forms of haemophagocytic lymphohistiocytosis (sHLH) What? A subset of
• Infection (eg ... Hypofibrinogenemia • ↑ PT ↑ PTT ... Activation #Syndrome #Diagnosis ... #Management #Hematology ... #Rheumatology
Leukostasis vs Tumor Lysis Syndrome Leukostasis: • Pathophysiology: Large, immature blasts and high WBC count cause hyperviscosity
high WBC count cause ... unless worrisome EKG ... Syndrome #TLS #diagnosis ... #management #hematology
SAPHO Syndrome Summary What? SAPHO syndrome is a rare chronic inflammatory disorder of bone, joint, and skin characterized
• A clinical diagnosis ... Rule out other causes ... antiinflammatory properties e.g ... #diagnosis #management ... #Dermatology
Blood Product Transfusions One Pager Summary Type and screen - determines blood type and detects in recipient
in recipient (e.g ... Causes purpura & ... TRALI): Leading cause ... #Transfusions #diagnosis ... #management #hematology
Essential Thrombocythemia (ET) ET is a chronic myeloproliferative neoplasm. Most cases are related to mutations that affect
Most cases are related ... Splenomegaly Diagnosis ... Thrombocythemia #ET #hematology ... #diagnosis #management ... #hematology
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