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Nephron - Diuretic Sites of Action

Source Text: https://www.sciencedirect.com/book/9780323449427/critical-care-nephrology#book-info

#Nephron #Diuretics #Site #Action #Location #Nephrology #Pathophysiology #Pharmacology
Nephron - Diuretic ... Sites of Action ... book-info #Nephron #Diuretics ... #Site #Action # ... #Pathophysiology
Nephron Pathophysiology - Diuretic Sites of Action
Diuretics
1) Acetazolamide/canagliflozin
2) Osmotic agents (mannitol, urearetics)
3) Loop agents (eg, furosemide)
4)
Nephron Pathophysiology ... - Diuretic Sites ... ) Loop agents (eg ... #Diuretics #Sites ... #Action #nephrology
Diuretics sites of action on the nephron
1) Acetazolamide (carbonic anhydrase inhibitor)
2) Osmotic diuretics (e.g. mannitol)
3) Loop
Diuretics sites ... (e.g. mannitol) ... (e.g. ... #pharmacology #nephrology ... #medications #sites
Hormones Acting on the Nephron - Diuretics and Their Site of Action
 1) Acetazolamide
 2) Osmotic
the Nephron - Diuretics ... and Their Site ... 3) Loop Diuretics ... spironolactone) #Pathophysiology ... #Nephrology #Nephron
Causes of Metabolic Alkalosis: Differential Diagnosis
ECF volume contracted: urine chloride concentration <20 meq/L
 • Gastric alkalosis:
Thiazide or loop diuretics ... after renal tubule diuretic ... Thiazide or loop diuretics ... thiazide-sensitive site ... Diagnosis #Causes #nephrology
Diuretics and Agents Regulating Renal Excretion

Carbonic Anhydrase Inhibitors (Acetazolamide, Dichlorphenamide)
 • Glaucoma
 • Epilepsy
 • Altitude
Diuretics and Agents ... • Metabolic alkalosis ... Symport (Loop Diuretics ... Postoperative abdominal distention ... #Nephrology #Pharmacology
Causes of Secondary Hypertension - Workup and Differential Diagnosis
Approach (when evaluation should be done):
1. Severe or
classes, including a diuretic ... risk factors (eg ... heart failure, neurologic ... and metabolic alkalosis ... Neurologic disorders
Gitelman Syndrome Overview

What?
• Inherited (AR) hypokalemic salt-losing tubulopathies affecting the thiazide-sensitive sodium chloride cotransporter
• Gitelman's syndrome
with thiazide diuretic ... hypomagnesemia • Metabolic alkalosis ... Hypochloremic metabolic alkalosis ... Surreptitious diuretic ... #management #pathophysiology