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Nephron - Diuretic Sites of Action

Source Text: https://www.sciencedirect.com/book/9780323449427/critical-care-nephrology#book-info

#Nephron #Diuretics #Site #Action #Location #Nephrology #Pathophysiology #Pharmacology
Nephron - Diuretic ... Sites of Action ... book-info #Nephron #Diuretics ... #Site #Action # ... #Pathophysiology
Nephron Pathophysiology - Diuretic Sites of Action
Diuretics
1) Acetazolamide/canagliflozin
2) Osmotic agents (mannitol, urearetics)
3) Loop agents (eg, furosemide)
4)
- Diuretic Sites ... of Action Diuretics ... ) Loop agents (eg ... #Diuretics #Sites ... #Action #nephrology
Diuretics sites of action on the nephron
1) Acetazolamide (carbonic anhydrase inhibitor)
2) Osmotic diuretics (e.g. mannitol)
3) Loop
Diuretics sites ... of action on the ... 3) Loop diuretic ... Thiazides-type diuretics ... #pharmacology #nephrology
Hormones Acting on the Nephron - Diuretics and Their Site of Action
 1) Acetazolamide
 2) Osmotic
the Nephron - Diuretics ... and Their Site ... 2) Osmotic Diuretics ... 3) Loop Diuretics ... #Diuretics #Hormones
Causes of Hypokalemia
Transcellular Shifts:
 - Alkalosis, Increased plasma insulin (treatment of diabetic ketoacidosis), ß-Adrenergic agonists, Hypokalemic
Transcellular Shifts: - Alkalosis ... thiazide-like diuretics ... Postobstructive diuresis ... , Osmotic diuresis ... mimics thiazide diuretic
Diuretics and Agents Regulating Renal Excretion

Carbonic Anhydrase Inhibitors (Acetazolamide, Dichlorphenamide)
 • Glaucoma
 • Epilepsy
 • Altitude
Diuretics and Agents ... • Metabolic alkalosis ... ; High-Ceiling Diuretics ... Kidney stones caused ... Postoperative abdominal distention
Causes of Metabolic Alkalosis: Differential Diagnosis
ECF volume contracted: urine chloride concentration <20 meq/L
 • Gastric alkalosis:
Causes of Metabolic ... Thiazide or loop diuretics ... after renal tubule diuretic ... Thiazide or loop diuretics ... thiazide-sensitive site
Primary Metabolic Alkalosis - Differential Diagnosis Algorithm
Volume Depleted - 2° hyperaldosteronism
 • Low Urine Cl-: Vomiting,
Primary Metabolic Alkalosis ... Vomiting, NGT suction ... Low Cl intake, Diuretics ... High Urine Cl-: Diuretics ... #Causes
Metabolic Alkalosis - Urinary Chloride Algorithm
Cl- responsive metabolic alkalosis
 • Kidney loss of Cl-
loop or thiazide diuretics ... blood pressure: Active ... diuretic use, Bartter ... the indicated causes ... urine #Algorithm #nephrology
Causes of Metabolic Alkalosis - Differential Diagnosis Algorithm
GI Losses - Gastric
 • Vomiting
 • NG suction
GI
Causes of Metabolic ... Alkalosis - Differential ... Vomiting • NG suction ... tubular transport • Diuretics ... Diagnosis #Algorithm #Causes