15 results
Cholestatic Liver Disease: Primary Biliary Cirrhosis vs Primary Sclerosing Cholangitis

#pathophysiology #pbc #psc #hepatology #comparison
Cholangitis #pathophysiology ... #pbc #psc #hepatology
Pathophysiology of Hemolytic Anemia
 - Defects in RBC internal contents (thalassemia, hemoglobinopathies, and metabolic defects)
 -
Pathophysiology ... - Defects in RBC ... - Defects in RBC ... environment #Pathophysiology ... Hemolytic #Anemia #hematology
Ascites - Differential Diagnosis and Workup Algorithm

•
Perform paracentesis:
 • Cell count and diff 
 • Total
• Perform paracentesis ... Check ascites WBC ... gastroenterology #hepatology
Primary Biliary Cirrhosis - Pathophysiology
Environmental Risk Factors: Geographic location, Smoking, Microbial triggers, Xenobiotics, Nail polish
Epigentics Risk
Biliary Cirrhosis - Pathophysiology ... relative with PBC ... Pathophysiology ... Cholestasis #PBC ... #hepatology
Primary Biliary Cirrhosis (PBC) - Summary

PBC Epidemiology:
 • Female:Male 9:1
 • Common European descent
 • Age:
Biliary Cirrhosis (PBC ... ) - Summary PBC ... 30-65 years PBC ... Pathophysiology ... diagnosis #workup #hepatology
Sickle Cell Disease - Pathophysiology of disease and complications 

Due to the deformed shape, HbS induces
Cell Disease - Pathophysiology ... shape, HbS induces RBC ... This leads to RBC ... SickleCell #Disease #Pathophysiology ... Complications #Hematology
Leukostasis vs Tumor Lysis Syndrome
Leukostasis:
 • Pathophysiology: Large, immature blasts and high WBC count cause hyperviscosity
Leukostasis: • Pathophysiology ... blasts and high WBC ... • Lab values: WBC ... Lysis Syndrome: • Pathophysiology ... diagnosis #management #hematology
Ascites - Diagnosis and Management Summary
Paracentesis studies: cell count + differential, albumin, protein, culture
 • Serum-ascites-albumin-gradient
Management Summary Paracentesis ... SBP: PMN count (WBC ... ) Large-volume paracentesis ... Management #Summary #Hepatology ... #SAAG #paracentesis
Bandemia Overview

Normal: < 1%
Clinically significant: > 10%

Band neutrophils are slightly less mature than segmented neutrophils and
Even with normal WBC ... relative to both WBC ... 21% had normal WBC ... #CBC #hematology ... #pathophysiology
Differentiation Syndrome in APML
Epidemiology:
 • Incidence: common in APL (2-48% depending on the study)
 • Triggers:
ATRA treatment Pathophysiology ... if high risk if WBC ... QD until normal WBC ... fluid overload, PCC ... diagnosis #management #hematology