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diagnosis clinical management differential nephrology pharmacology algorithm pocus cardiology pathophysiology causes ultrasound treatment radiology hyponatremia obgyn table classification criticalcare comparison
#paracetamol #paracetamoloverdose #NAC
#paracetamol #paracetamoloverdose ... #NAC
N-Acetyl Cysteine (NAC) Therapy Mechanism of Action: The non-toxic route of APAP metabolism gets saturated in
N-Acetyl Cysteine (NAC ... NAC helps replenish ... Figure 2.1 NAC has ... GSH) precursor, NAC3 ... substitute, and NAC4
Thiazide diuretics Carbonic anhydrase inhibitors (e.g., acetazolamide) Nat-Cl symport Na and HCO;- reabsorption Aldosterone antagonists (e.g., spironolactone) Nat channel (indirect effect) Loop diuretics (e.g., furosemide) Amiloride, #triamterene Nat-K+-2CF symport Na channel (direct effect) #NaCI reabsorption
acetazolamide) Nat-Cl ... symport Na and ... spironolactone) Nat ... +-2CF symport Na ... direct effect) #NaCI
5-Oxoprolinuria What is it: • Aka pyroglutamic acidosis, Intermediate in γ-glutamyl cycle • Amino acid transport and
Link to chronic paracetamol ... • Continuous paracetamol ... Diagnosis: • HAGMA; Paracetamol ... HDU • Withdraw paracetamol
Diagnostic criteria for Neutropenic Enterocolitis (NEC) Major Criteria: • Neutropenia (ANC <500 x 10^9 cells/L) • Bowel
Enterocolitis (NEC ... • Neutropenia (ANC ... 1min_idconsult #NEC
Drugs that Impair Renal Potassium Excretion Decreased ENaC channel function: Amiloride, Triamterene, Pentamidine Decreased Aldosterone Synthesis: Heparin,
Decreased ENaC ... Beta-Blockers Decreased Na
Obstetric Ultrasound Pocket Card 1st Trimester Checklist: • Look for signs of an IUP • Gestational dating
dating • Mean sac ... biometrics: BPD, HC, AC
The 3 Fates of a Premature Atrial Complex • PAC can be conducted with normal QRS
Atrial Complex • PAC ... • PAC can be ... aberrancy - A PAC ... • PAC can be ... non- conducted PAC
Restarting Anticoagulation after TIA or Acute Ischemic Stroke • TIA → Consider (re-) starting a NOAC
re-) starting a NOAC ... re-) starting a NOAC ... re-)starting a NOAC ... re-) starting a NOAC ... re-)starting a NOAC
Addictions: Pathogenesis Mesolimbic Dopaminergic Pathway: • Dopaminergic neurons in Ventral Tegmental Area (VTA) in midbrain under continuous
Nucleus Accumbens (NAc ... ) • The NAC receives ... response) • The NAC
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